Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM327027
((3R)-1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- ...)Show SMILES O[C@@H]1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)C1 |r| Show InChI InChI=1S/C19H21NO3/c21-16-9-10-20(12-16)11-14-5-7-15(8-6-14)19-13-22-17-3-1-2-4-18(17)23-19/h1-8,16,19,21H,9-13H2/t16-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM327050
((3R)-1-[4-(2,3-dihydro-1,4- benzodioxin-2- yl)be...)Show SMILES O[C@@H]1CCN(Cc2ccc(cc2)C2COc3ccccc3O2)C1 |r| Show InChI InChI=1S/C19H21NO3/c21-16-9-10-20(12-16)11-14-5-7-15(8-6-14)19-13-22-17-3-1-2-4-18(17)23-19/h1-8,16,19,21H,9-13H2/t16-,19?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.89 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |