Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neprilysin
(Homo sapiens (Human)) | BDBM298321
((R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N...)Show SMILES O[C@H](CN(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C18H17ClN2O6/c19-14-3-1-2-13(8-14)12-6-4-11(5-7-12)9-21(10-15(22)17(24)25)20-16(23)18(26)27/h1-8,15,22H,9-10H2,(H,20,23)(H,24,25)(H,26,27)/t15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| 3.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
THERAVANCE BIOPHARMA R&D IP, LLC
US Patent
| Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa... |
US Patent US10123984 (2018)
BindingDB Entry DOI: 10.7270/Q2KK9DVB |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM298321
((R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N...)Show SMILES O[C@H](CN(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C18H17ClN2O6/c19-14-3-1-2-13(8-14)12-6-4-11(5-7-12)9-21(10-15(22)17(24)25)20-16(23)18(26)27/h1-8,15,22H,9-10H2,(H,20,23)(H,24,25)(H,26,27)/t15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| US Patent
| 3.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa... |
US Patent US10744104 (2020)
BindingDB Entry DOI: 10.7270/Q2PG1VT4 |
More data for this Ligand-Target Pair | |
Neprilysin/Angiotensin-converting enzyme
(Homo sapiens (Human)) | BDBM298321
((R)-3-[N-(3′-Chlorobiphenyl-4-ylmethyl)-N...)Show SMILES O[C@H](CN(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C18H17ClN2O6/c19-14-3-1-2-13(8-14)12-6-4-11(5-7-12)9-21(10-15(22)17(24)25)20-16(23)18(26)27/h1-8,15,22H,9-10H2,(H,20,23)(H,24,25)(H,26,27)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
| | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2PR8136 |
More data for this Ligand-Target Pair | |