Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Competitive inhibition of recombinant glucocerebrosidase |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 7.4 after 10 mins by fluorometric analysis |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 5.2 | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 5.2 after 10 mins by fluorometric analysis |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Beta-galactosidase
(Bos taurus (Bovine)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of bovine liver beta-galactosidase |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Alpha-galactosidase
(Coffea arabica (Coffee beans)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of alpha-galactosidase from coffee beans |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Oligo-1,6-glucosidase IMA1
(Saccharomyces cerevisiae S288c (Baker's yeast)) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of yeast alpha-glucosidase |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |
Probable alpha-glucosidase Os06g0675700
(Oryza sativa subsp. japonica) | BDBM50341334
(CHEMBL1766473 | rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-...)Show SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O |r,TLB:12:13:16:20.19.18,THB:14:15:18:22.13.21,14:13:16.15.20:18,21:13:16:20.19.18,21:19:16:22.14.13,12:13:16.15.20:18| Show InChI InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas)
Curated by ChEMBL
| Assay Description Inhibition of rice alpha-glucosidase |
J Med Chem 54: 2069-79 (2011)
Article DOI: 10.1021/jm101204u BindingDB Entry DOI: 10.7270/Q24F1R18 |
More data for this Ligand-Target Pair | |