Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 569.6 BDBM165099

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM165099 (US9067917, 134 | US9682971, 134) Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(cc1)-c1cncnc1 |r| Show InChI InChI=1S/C35H31N5O3/c41-35(42)30-7-3-2-6-29(30)34-39-32-17-28(43-21-27-14-13-25-5-1-4-8-31(25)38-27)15-16-33(32)40(34)20-23-9-11-24(12-10-23)26-18-36-22-37-19-26/h1,4-5,8-19,22,29-30H,2-3,6-7,20-21H2,(H,41,42)/t29?,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9682971 (2017) BindingDB Entry DOI: 10.7270/Q2P26W84
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM165099 (US9067917, 134 | US9682971, 134) Show SMILES OC(=O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(cc1)-c1cncnc1 |r| Show InChI InChI=1S/C35H31N5O3/c41-35(42)30-7-3-2-6-29(30)34-39-32-17-28(43-21-27-14-13-25-5-1-4-8-31(25)38-27)15-16-33(32)40(34)20-23-9-11-24(12-10-23)26-18-36-22-37-19-26/h1,4-5,8-19,22,29-30H,2-3,6-7,20-21H2,(H,41,42)/t29?,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9067917 (2015) BindingDB Entry DOI: 10.7270/Q24748M5
					More data for this Ligand-Target Pair