Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polymerase acidic protein
(Hepatitis C virus) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center
Curated by ChEMBL
| Assay Description Binding affinity to PA N-terminal domain (Competitive) |
ACS Chem Biol 7: 526-34 (2012)
Article DOI: 10.1021/cb200439z BindingDB Entry DOI: 10.7270/Q2JQ121G |
More data for this Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys, Inc.
Curated by ChEMBL
| Assay Description Concentration required for 50% inhibition of Flap endonuclease-1 |
Bioorg Med Chem Lett 14: 4915-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF |
More data for this Ligand-Target Pair | |
DNA excision repair protein ERCC-5
(Homo sapiens (Human)) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys, Inc.
Curated by ChEMBL
| Assay Description Concentration required for 50% inhibition of Xeroderma pigmentosum G |
Bioorg Med Chem Lett 14: 4915-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.028 BindingDB Entry DOI: 10.7270/Q2ZC82BF |
More data for this Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute/NIH
Curated by ChEMBL
| Assay Description Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1 |
J Med Chem 45: 3184-94 (2002)
BindingDB Entry DOI: 10.7270/Q26D5TPD |
More data for this Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Messina
Curated by ChEMBL
| Assay Description Strand transfer inhibitory activity against HIV-1 integrase |
J Med Chem 48: 7084-8 (2005)
Article DOI: 10.1021/jm050549e BindingDB Entry DOI: 10.7270/Q27W6BR1 |
More data for this Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute/NIH
Curated by ChEMBL
| Assay Description Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2 |
J Med Chem 45: 3184-94 (2002)
BindingDB Entry DOI: 10.7270/Q26D5TPD |
More data for this Ligand-Target Pair | |
Integrase
(Human immunodeficiency virus 1) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute/NIH
Curated by ChEMBL
| Assay Description Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay |
J Med Chem 45: 3184-94 (2002)
BindingDB Entry DOI: 10.7270/Q26D5TPD |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
(Hepatitis C virus) | BDBM50115581
((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)Show InChI InChI=1S/C16H12O5/c17-14(10-15(18)16(19)20)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,10H2,(H,19,20) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center
Curated by ChEMBL
| Assay Description Plaque growth inhibition |
ACS Chem Biol 7: 526-34 (2012)
Article DOI: 10.1021/cb200439z BindingDB Entry DOI: 10.7270/Q2JQ121G |
More data for this Ligand-Target Pair | |