Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C motif chemokine 10
(Homo sapiens (Human)) | BDBM249591
(US9447038, 19)Show SMILES OC(=O)C[C@H](N(CC1CC1)Cc1ccc(OCCN2C(=O)CCC2=O)c(F)c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H27ClF2N2O5/c27-19-5-4-18(12-20(19)28)22(13-26(34)35)30(14-16-1-2-16)15-17-3-6-23(21(29)11-17)36-10-9-31-24(32)7-8-25(31)33/h3-6,11-12,16,22H,1-2,7-10,13-15H2,(H,34,35)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi
US Patent
| Assay Description The composition of the binding assay buffer is determined in a course of detailed optimization procedure. This resulted in a binding assay buffer con... |
US Patent US9447038 (2016)
BindingDB Entry DOI: 10.7270/Q29G5KQK |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM249591
(US9447038, 19)Show SMILES OC(=O)C[C@H](N(CC1CC1)Cc1ccc(OCCN2C(=O)CCC2=O)c(F)c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H27ClF2N2O5/c27-19-5-4-18(12-20(19)28)22(13-26(34)35)30(14-16-1-2-16)15-17-3-6-23(21(29)11-17)36-10-9-31-24(32)7-8-25(31)33/h3-6,11-12,16,22H,1-2,7-10,13-15H2,(H,34,35)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Co. Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-CXCL10 from human recombinant CXCR3 transfected in Flp-In-CHO cell membranes after 60 mins by gamma counting method |
Bioorg Med Chem Lett 26: 5429-5437 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.038 BindingDB Entry DOI: 10.7270/Q2514164 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM249591
(US9447038, 19)Show SMILES OC(=O)C[C@H](N(CC1CC1)Cc1ccc(OCCN2C(=O)CCC2=O)c(F)c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H27ClF2N2O5/c27-19-5-4-18(12-20(19)28)22(13-26(34)35)30(14-16-1-2-16)15-17-3-6-23(21(29)11-17)36-10-9-31-24(32)7-8-25(31)33/h3-6,11-12,16,22H,1-2,7-10,13-15H2,(H,34,35)/t22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 26: 5429-5437 (2016)
Article DOI: 10.1016/j.bmcl.2016.10.038 BindingDB Entry DOI: 10.7270/Q2514164 |
More data for this Ligand-Target Pair | |