Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50009393
(CHEMBL3233874)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2nc(Nc3ccccc3)ncc2c1 |r,wU:7.10,wD:4.3,(43.43,-15.9,;43.42,-14.37,;44.75,-13.58,;42.08,-13.61,;40.75,-14.39,;39.41,-13.63,;38.08,-14.41,;38.1,-15.94,;39.44,-16.7,;40.76,-15.93,;36.77,-16.72,;36.78,-18.27,;35.46,-19.05,;34.12,-18.28,;34.1,-16.75,;35.42,-15.97,;32.79,-19.07,;32.81,-20.6,;31.49,-21.38,;30.15,-20.63,;28.82,-21.43,;27.47,-20.69,;26.15,-21.49,;24.8,-20.75,;24.77,-19.21,;23.42,-18.47,;22.11,-19.27,;22.15,-20.82,;23.5,-21.55,;27.43,-19.13,;28.76,-18.33,;30.12,-19.08,;31.45,-18.3,)| Show InChI InChI=1S/C28H27N3O2/c32-27(33)16-19-6-8-20(9-7-19)21-10-12-22(13-11-21)23-14-15-26-24(17-23)18-29-28(31-26)30-25-4-2-1-3-5-25/h1-5,10-15,17-20H,6-9,16H2,(H,32,33)(H,29,30,31)/t19-,20- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DGAT1 |
Bioorg Med Chem Lett 24: 1790-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.028 BindingDB Entry DOI: 10.7270/Q2DR2X19 |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50009393
(CHEMBL3233874)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2nc(Nc3ccccc3)ncc2c1 |r,wU:7.10,wD:4.3,(43.43,-15.9,;43.42,-14.37,;44.75,-13.58,;42.08,-13.61,;40.75,-14.39,;39.41,-13.63,;38.08,-14.41,;38.1,-15.94,;39.44,-16.7,;40.76,-15.93,;36.77,-16.72,;36.78,-18.27,;35.46,-19.05,;34.12,-18.28,;34.1,-16.75,;35.42,-15.97,;32.79,-19.07,;32.81,-20.6,;31.49,-21.38,;30.15,-20.63,;28.82,-21.43,;27.47,-20.69,;26.15,-21.49,;24.8,-20.75,;24.77,-19.21,;23.42,-18.47,;22.11,-19.27,;22.15,-20.82,;23.5,-21.55,;27.43,-19.13,;28.76,-18.33,;30.12,-19.08,;31.45,-18.3,)| Show InChI InChI=1S/C28H27N3O2/c32-27(33)16-19-6-8-20(9-7-19)21-10-12-22(13-11-21)23-14-15-26-24(17-23)18-29-28(31-26)30-25-4-2-1-3-5-25/h1-5,10-15,17-20H,6-9,16H2,(H,32,33)(H,29,30,31)/t19-,20- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of mouse DGAT1 |
Bioorg Med Chem Lett 24: 1790-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.028 BindingDB Entry DOI: 10.7270/Q2DR2X19 |
More data for this Ligand-Target Pair | |