Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50317483
((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)Show SMILES OC(=O)CCCN1CCCC[C@@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C22H26ClNO4/c23-17-6-8-20(9-7-17)28-21-12-10-19(11-13-21)27-16-18-4-1-2-14-24(18)15-3-5-22(25)26/h6-13,18H,1-5,14-16H2,(H,25,26)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA |
Bioorg Med Chem Lett 20: 2851-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.047
BindingDB Entry DOI: 10.7270/Q2CC10VD |
More data for this
Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50317483
((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)Show SMILES OC(=O)CCCN1CCCC[C@@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C22H26ClNO4/c23-17-6-8-20(9-7-17)28-21-12-10-19(11-13-21)27-16-18-4-1-2-14-24(18)15-3-5-22(25)26/h6-13,18H,1-5,14-16H2,(H,25,26)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS |
Bioorg Med Chem Lett 20: 2851-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.047
BindingDB Entry DOI: 10.7270/Q2CC10VD |
More data for this
Ligand-Target Pair | |