Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 463.4 BDBM50286914

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Rattus norvegicus (Rat))	BDBM50286914 ((2R,4R)-4-(Biphenyl-4-yloxy)-4-(carboxymethyl-carb...) Show SMILES OC(=O)CNC(=O)[C@@H](C[C@H](COc1ccccc1)C(O)=O)Oc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C26H25NO7/c28-24(29)16-27-25(30)23(15-20(26(31)32)17-33-21-9-5-2-6-10-21)34-22-13-11-19(12-14-22)18-7-3-1-4-8-18/h1-14,20,23H,15-17H2,(H,27,30)(H,28,29)(H,31,32)/t20-,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of neutral endopeptidase from rat kidney.				Bioorg Med Chem Lett 6: 65-70 (1996) Article DOI: 10.1016/0960-894X(95)00551-4 BindingDB Entry DOI: 10.7270/Q2BZ66J9
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