Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50364014
(CHEMBL1950402)Show SMILES OC(=O)Cc1cncc(c1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Br Show InChI InChI=1S/C22H20BrFN4O3/c23-18-2-1-16(24)11-20(18)31-17-5-7-28(8-6-17)21-4-3-19(26-27-21)15-9-14(10-22(29)30)12-25-13-15/h1-4,9,11-13,17H,5-8,10H2,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of rat SCD1 |
Bioorg Med Chem Lett 21: 7281-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.040
BindingDB Entry DOI: 10.7270/Q2G44QQZ |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50364014
(CHEMBL1950402)Show SMILES OC(=O)Cc1cncc(c1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Br Show InChI InChI=1S/C22H20BrFN4O3/c23-18-2-1-16(24)11-20(18)31-17-5-7-28(8-6-17)21-4-3-19(26-27-21)15-9-14(10-22(29)30)12-25-13-15/h1-4,9,11-13,17H,5-8,10H2,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in Sprague-Dawley rat hepatocytes assessed as conversion of [14C]oleic acid formation by HPLC analysis |
Bioorg Med Chem Lett 21: 7281-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.040
BindingDB Entry DOI: 10.7270/Q2G44QQZ |
More data for this
Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50364014
(CHEMBL1950402)Show SMILES OC(=O)Cc1cncc(c1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Br Show InChI InChI=1S/C22H20BrFN4O3/c23-18-2-1-16(24)11-20(18)31-17-5-7-28(8-6-17)21-4-3-19(26-27-21)15-9-14(10-22(29)30)12-25-13-15/h1-4,9,11-13,17H,5-8,10H2,(H,29,30) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of human SCD1 expressed in human HepG2 cells assessed as conversion of [14C]stearic acid to [14C]oleic acid |
Bioorg Med Chem Lett 21: 7281-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.040
BindingDB Entry DOI: 10.7270/Q2G44QQZ |
More data for this
Ligand-Target Pair | |