Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362591
(CHEMBL1938879)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCC2(CN(C2)c2cc(F)ccc2Cl)CC1 Show InChI InChI=1S/C19H19ClFN7O2S/c20-13-2-1-12(21)7-14(13)27-10-19(11-27)3-5-26(6-4-19)18-22-8-15(31-18)17-23-25-28(24-17)9-16(29)30/h1-2,7-8H,3-6,9-11H2,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in rat liver microsomes assessed as reduction in [1-14C] stearoyl CoA desaturation by scintillation counting |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362591
(CHEMBL1938879)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCC2(CN(C2)c2cc(F)ccc2Cl)CC1 Show InChI InChI=1S/C19H19ClFN7O2S/c20-13-2-1-12(21)7-14(13)27-10-19(11-27)3-5-26(6-4-19)18-22-8-15(31-18)17-23-25-28(24-17)9-16(29)30/h1-2,7-8H,3-6,9-11H2,(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 438 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in rat hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [1-14C] stearoyl CoA desa... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50362591
(CHEMBL1938879)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCC2(CN(C2)c2cc(F)ccc2Cl)CC1 Show InChI InChI=1S/C19H19ClFN7O2S/c20-13-2-1-12(21)7-14(13)27-10-19(11-27)3-5-26(6-4-19)18-22-8-15(31-18)17-23-25-28(24-17)9-16(29)30/h1-2,7-8H,3-6,9-11H2,(H,29,30) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [1-14C] stearoyl CoA des... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |