Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acyl-CoA desaturase 1
(Mus musculus) | BDBM50362587
(CHEMBL1938875)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCN(CC1)c1cc(F)ccc1Cl Show InChI InChI=1S/C16H15ClFN7O2S/c17-11-2-1-10(18)7-12(11)23-3-5-24(6-4-23)16-19-8-13(28-16)15-20-22-25(21-15)9-14(26)27/h1-2,7-8H,3-6,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of mouse SCD-1 |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362587
(CHEMBL1938875)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCN(CC1)c1cc(F)ccc1Cl Show InChI InChI=1S/C16H15ClFN7O2S/c17-11-2-1-10(18)7-12(11)23-3-5-24(6-4-23)16-19-8-13(28-16)15-20-22-25(21-15)9-14(26)27/h1-2,7-8H,3-6,9H2,(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in rat liver microsomes assessed as reduction in [1-14C] stearoyl CoA desaturation by scintillation counting |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362587
(CHEMBL1938875)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCN(CC1)c1cc(F)ccc1Cl Show InChI InChI=1S/C16H15ClFN7O2S/c17-11-2-1-10(18)7-12(11)23-3-5-24(6-4-23)16-19-8-13(28-16)15-20-22-25(21-15)9-14(26)27/h1-2,7-8H,3-6,9H2,(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in rat hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [1-14C] stearoyl CoA desa... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50362587
(CHEMBL1938875)Show SMILES OC(=O)Cn1nnc(n1)-c1cnc(s1)N1CCN(CC1)c1cc(F)ccc1Cl Show InChI InChI=1S/C16H15ClFN7O2S/c17-11-2-1-10(18)7-12(11)23-3-5-24(6-4-23)16-19-8-13(28-16)15-20-22-25(21-15)9-14(26)27/h1-2,7-8H,3-6,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [1-14C] stearoyl CoA des... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002
BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this
Ligand-Target Pair | |