Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362585
(CHEMBL1938873)Show SMILES OC(=O)Cn1nnc(n1)-c1nnc(s1)N1CC2CN(CC2C1)c1cc(F)ccc1Cl Show InChI InChI=1S/C17H16ClFN8O2S/c18-12-2-1-11(19)3-13(12)25-4-9-6-26(7-10(9)5-25)17-22-21-16(30-17)15-20-24-27(23-15)8-14(28)29/h1-3,9-10H,4-8H2,(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of SCD-1 activity in rat liver microsomes assessed as reduction in [1-14C] stearoyl CoA desaturation by scintillation counting |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002 BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50362585
(CHEMBL1938873)Show SMILES OC(=O)Cn1nnc(n1)-c1nnc(s1)N1CC2CN(CC2C1)c1cc(F)ccc1Cl Show InChI InChI=1S/C17H16ClFN8O2S/c18-12-2-1-11(19)3-13(12)25-4-9-6-26(7-10(9)5-25)17-22-21-16(30-17)15-20-24-27(23-15)8-14(28)29/h1-3,9-10H,4-8H2,(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of SCD-1 activity in rat hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [1-14C] stearoyl CoA desa... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002 BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50362585
(CHEMBL1938873)Show SMILES OC(=O)Cn1nnc(n1)-c1nnc(s1)N1CC2CN(CC2C1)c1cc(F)ccc1Cl Show InChI InChI=1S/C17H16ClFN8O2S/c18-12-2-1-11(19)3-13(12)25-4-9-6-26(7-10(9)5-25)17-22-21-16(30-17)15-20-24-27(23-15)8-14(28)29/h1-3,9-10H,4-8H2,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [1-14C] stearoyl CoA des... |
Bioorg Med Chem Lett 22: 980-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.002 BindingDB Entry DOI: 10.7270/Q2833SHH |
More data for this Ligand-Target Pair | |