Found 8 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393817
(US10597367, Example 105 | US9969726, Example 105)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H12F10N2O2/c27-19-5-4-13(9-18(19)23(39)40)12-2-1-3-14(6-12)22-37-20(11-21(38-22)26(34,35)36)15-7-16(24(28,29)30)10-17(8-15)25(31,32)33/h1-11H,(H,39,40) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this
Ligand-Target Pair | |