Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Rattus norvegicus) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
US Patent
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
US Patent US10597367 (2020)
BindingDB Entry DOI: 10.7270/Q2GB272Z |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM393820
(US10597367, Example 108 | US9969726, Example 108)Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H13F7N2O2/c26-19-9-6-15(11-18(19)23(35)36)14-2-1-3-16(10-14)22-33-20(12-21(34-22)25(30,31)32)13-4-7-17(8-5-13)24(27,28)29/h1-12H,(H,35,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza
| Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (... |
J Med Chem 52: 1935-42 (2009)
BindingDB Entry DOI: 10.7270/Q2RX9FDX |
More data for this Ligand-Target Pair | |