Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM50416302
(CHEMBL1171586)Show SMILES OC(=O)c1ccccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3NO5S/c21-13-6-8-14(9-7-13)31(28,29)25-16-11-12(20(22,23)24)5-10-18(16)30-17-4-2-1-3-15(17)19(26)27/h1-11,25H,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR1 assessed as inhibition of MIP-1-alpha-induced [35S]-GTPgammaS binding after 3 to 4 hrs |
Bioorg Med Chem Lett 20: 3961-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.142
BindingDB Entry DOI: 10.7270/Q2B56KZ9 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50416302
(CHEMBL1171586)Show SMILES OC(=O)c1ccccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3NO5S/c21-13-6-8-14(9-7-13)31(28,29)25-16-11-12(20(22,23)24)5-10-18(16)30-17-4-2-1-3-15(17)19(26)27/h1-11,25H,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR2 expressed in CHO cells assessed as inhibition of MCP1-induced [35S]-GTPgammaS binding after 3 hrs |
Bioorg Med Chem Lett 20: 3961-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.142
BindingDB Entry DOI: 10.7270/Q2B56KZ9 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Mus musculus) | BDBM50416302
(CHEMBL1171586)Show SMILES OC(=O)c1ccccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3NO5S/c21-13-6-8-14(9-7-13)31(28,29)25-16-11-12(20(22,23)24)5-10-18(16)30-17-4-2-1-3-15(17)19(26)27/h1-11,25H,(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse CCR2 |
Bioorg Med Chem Lett 20: 3961-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.142
BindingDB Entry DOI: 10.7270/Q2B56KZ9 |
More data for this
Ligand-Target Pair | |