Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50306120
(6-(7-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine...)Show SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(O)c1ccc(F)cc1O2)c1ccccc1 Show InChI InChI=1S/C26H27FN4O4/c27-18-6-7-19-21(32)15-26(35-23(19)14-18)10-12-31(13-11-26)24-9-8-20(29-30-24)25(34)28-16-22(33)17-4-2-1-3-5-17/h1-9,14,21-22,32-33H,10-13,15-16H2,(H,28,34) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in human 293A cells assessed as conversion of [14C]stearate to [14C]oleate after 60 mins in presence of S9 microsomal fraction |
Bioorg Med Chem Lett 20: 746-54 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ |
More data for this Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Mus musculus) | BDBM50306120
(6-(7-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine...)Show SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(O)c1ccc(F)cc1O2)c1ccccc1 Show InChI InChI=1S/C26H27FN4O4/c27-18-6-7-19-21(32)15-26(35-23(19)14-18)10-12-31(13-11-26)24-9-8-20(29-30-24)25(34)28-16-22(33)17-4-2-1-3-5-17/h1-9,14,21-22,32-33H,10-13,15-16H2,(H,28,34) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 548 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins |
Bioorg Med Chem Lett 20: 746-54 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.043 BindingDB Entry DOI: 10.7270/Q28C9WBJ |
More data for this Ligand-Target Pair | |