Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50328297
(2-hydroxy-5-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]...)Show SMILES OC(CNC1CCN(CC1)c1ncnc2scc(-c3ccccc3)c12)COc1ccc(O)c(c1)C(O)=O Show InChI InChI=1S/C27H28N4O5S/c32-19(14-36-20-6-7-23(33)21(12-20)27(34)35)13-28-18-8-10-31(11-9-18)25-24-22(17-4-2-1-3-5-17)15-37-26(24)30-16-29-25/h1-7,12,15-16,18-19,28,32-33H,8-11,13-14H2,(H,34,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 6108-15 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.039 BindingDB Entry DOI: 10.7270/Q2WM1DNR |
More data for this Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50328297
(2-hydroxy-5-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]...)Show SMILES OC(CNC1CCN(CC1)c1ncnc2scc(-c3ccccc3)c12)COc1ccc(O)c(c1)C(O)=O Show InChI InChI=1S/C27H28N4O5S/c32-19(14-36-20-6-7-23(33)21(12-20)27(34)35)13-28-18-8-10-31(11-9-18)25-24-22(17-4-2-1-3-5-17)15-37-26(24)30-16-29-25/h1-7,12,15-16,18-19,28,32-33H,8-11,13-14H2,(H,34,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay |
Bioorg Med Chem Lett 20: 6108-15 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.039 BindingDB Entry DOI: 10.7270/Q2WM1DNR |
More data for this Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM50328297
(2-hydroxy-5-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]...)Show SMILES OC(CNC1CCN(CC1)c1ncnc2scc(-c3ccccc3)c12)COc1ccc(O)c(c1)C(O)=O Show InChI InChI=1S/C27H28N4O5S/c32-19(14-36-20-6-7-23(33)21(12-20)27(34)35)13-28-18-8-10-31(11-9-18)25-24-22(17-4-2-1-3-5-17)15-37-26(24)30-16-29-25/h1-7,12,15-16,18-19,28,32-33H,8-11,13-14H2,(H,34,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 310 | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay |
Bioorg Med Chem Lett 20: 6108-15 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.039 BindingDB Entry DOI: 10.7270/Q2WM1DNR |
More data for this Ligand-Target Pair | |