Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50086663
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50086663
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ... |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50086663
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex; Not Active means Ki >1000... |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Canis familiaris) | BDBM50086663
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |