Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM440792
(US10639284, Compound 2.139 | US10639284, Compound ...)Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA... |
US Patent US10639284 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5043 |
More data for this
Ligand-Target Pair | |
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM440792
(US10639284, Compound 2.139 | US10639284, Compound ...)Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K93BSK |
More data for this
Ligand-Target Pair | |
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM440792
(US10639284, Compound 2.139 | US10639284, Compound ...)Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K93BSK |
More data for this
Ligand-Target Pair | |
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM440792
(US10639284, Compound 2.139 | US10639284, Compound ...)Show SMILES OC[C@H](NCc1cc(Cl)c(O[C@@H]2CCc3c2cccc3-c2ccccc2F)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C32H27ClFN3O5/c33-26-11-21(16-37-28(17-38)32(39)40)30(41-18-20-10-19(13-35)14-36-15-20)12-31(26)42-29-9-8-23-22(5-3-6-25(23)29)24-4-1-2-7-27(24)34/h1-7,10-12,14-15,28-29,37-38H,8-9,16-18H2,(H,39,40)/t28-,29+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description
Plates were coated with 1 μg/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with PBS containing 2% BSA... |
US Patent US10639284 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5043 |
More data for this
Ligand-Target Pair | |