Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349665
(CHEMBL1809030)Show SMILES OC1CCC(CC1)NC(=O)N1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N1CCCC1 |r,wU:12.30,wD:15.16,c:14,(40.36,-4.55,;39.03,-3.78,;37.69,-4.54,;36.36,-3.77,;36.37,-2.22,;37.7,-1.46,;39.03,-2.24,;35.04,-1.45,;33.71,-2.22,;33.71,-3.76,;32.38,-1.45,;32.39,.1,;31.05,.88,;29.7,.1,;29.71,-1.44,;31.05,-2.22,;31.05,-3.76,;29.72,-4.54,;29.06,-6,;27.52,-6.01,;27.05,-4.54,;25.72,-3.77,;25.73,-2.23,;27.04,-1.47,;28.37,-2.23,;28.38,-3.77,;31.05,2.41,;29.72,3.18,;32.38,3.18,;33.78,2.55,;34.8,3.69,;34.03,5.02,;32.54,4.7,)| Show InChI InChI=1S/C26H32N4O3/c31-19-8-6-18(7-9-19)28-26(33)30-15-17(25(32)29-10-1-2-11-29)12-21-20-4-3-5-22-24(20)16(14-27-22)13-23(21)30/h3-5,12,14,17-19,23,27,31H,1-2,6-11,13,15H2,(H,28,33)/t17-,18?,19?,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Antagonist activity at human CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070
BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349665
(CHEMBL1809030)Show SMILES OC1CCC(CC1)NC(=O)N1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N1CCCC1 |r,wU:12.30,wD:15.16,c:14,(40.36,-4.55,;39.03,-3.78,;37.69,-4.54,;36.36,-3.77,;36.37,-2.22,;37.7,-1.46,;39.03,-2.24,;35.04,-1.45,;33.71,-2.22,;33.71,-3.76,;32.38,-1.45,;32.39,.1,;31.05,.88,;29.7,.1,;29.71,-1.44,;31.05,-2.22,;31.05,-3.76,;29.72,-4.54,;29.06,-6,;27.52,-6.01,;27.05,-4.54,;25.72,-3.77,;25.73,-2.23,;27.04,-1.47,;28.37,-2.23,;28.38,-3.77,;31.05,2.41,;29.72,3.18,;32.38,3.18,;33.78,2.55,;34.8,3.69,;34.03,5.02,;32.54,4.7,)| Show InChI InChI=1S/C26H32N4O3/c31-19-8-6-18(7-9-19)28-26(33)30-15-17(25(32)29-10-1-2-11-29)12-21-20-4-3-5-22-24(20)16(14-27-22)13-23(21)30/h3-5,12,14,17-19,23,27,31H,1-2,6-11,13,15H2,(H,28,33)/t17-,18?,19?,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Displacement of radiolabeled CXCL11 from human CXCR3 expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070
BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this
Ligand-Target Pair | |