Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132705
(US8841312, 455)Show SMILES OC1CCN(CC1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 Show InChI InChI=1S/C28H35N9O/c38-21-10-15-35(16-11-21)19-8-13-36(14-9-19)26-6-5-25(33-34-26)31-28-30-17-23-22-7-12-29-18-24(22)37(27(23)32-28)20-3-1-2-4-20/h5-7,12,17-21,38H,1-4,8-11,13-16H2,(H,30,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132705
(US8841312, 455)Show SMILES OC1CCN(CC1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 Show InChI InChI=1S/C28H35N9O/c38-21-10-15-35(16-11-21)19-8-13-36(14-9-19)26-6-5-25(33-34-26)31-28-30-17-23-22-7-12-29-18-24(22)37(27(23)32-28)20-3-1-2-4-20/h5-7,12,17-21,38H,1-4,8-11,13-16H2,(H,30,31,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |