Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial PAS domain-containing protein 1
(Homo sapiens (Human)) | BDBM372966
(US10597366, Compound 9 | US9896418, Compound 9)Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc.
US Patent
| Assay Description
HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1... |
US Patent US10597366 (2020)
BindingDB Entry DOI: 10.7270/Q2M32ZSW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372966
(US10597366, Compound 9 | US9896418, Compound 9)Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc.
US Patent
| Assay Description
VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a... |
US Patent US10597366 (2020)
BindingDB Entry DOI: 10.7270/Q2M32ZSW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372966
(US10597366, Compound 9 | US9896418, Compound 9)Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
The Scripps Research Institute
| Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-... |
J Med Chem 50: 3359-68 (2007)
BindingDB Entry DOI: 10.7270/Q2FN18HM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor A
(Homo sapiens (Human)) | BDBM372966
(US10597366, Compound 9 | US9896418, Compound 9)Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Research Triangle Institute
| Assay Description
Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad... |
J Med Chem 50: 3686-95 (2007)
BindingDB Entry DOI: 10.7270/Q2QC05TR |
More data for this
Ligand-Target Pair | |