Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 370.8 BDBM50172517

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase catalytic subunit (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human cytomegalovirus (HCMV strain AD169) )	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase delta catalytic subunit (Homo sapiens (Human))	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50172517 (4-Hydroxy-6-(3-hydroxy-propyl)-quinoline-3-carboxy...) Show SMILES OCCCc1ccc2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-15-6-3-14(4-7-15)11-23-20(26)17-12-22-18-8-5-13(2-1-9-24)10-16(18)19(17)25/h3-8,10,12,24H,1-2,9,11H2,(H,22,25)(H,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair