Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 567.0 BDBM50318171

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50318171 (2-{2-[bis(2-hydroxyethyl)amino]ethyl}-N-(4-chlorob...) Show SMILES OCCN(CCO)CCc1cc2cc(CN3CCOCC3)cc3c2n1cc(C(=O)NCc1ccc(Cl)cc1)c3=O Show InChI InChI=1S/C30H35ClN4O5/c31-24-3-1-21(2-4-24)18-32-30(39)27-20-35-25(5-6-33(7-11-36)8-12-37)17-23-15-22(16-26(28(23)35)29(27)38)19-34-9-13-40-14-10-34/h1-4,15-17,20,36-37H,5-14,18-19H2,(H,32,39)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha				Bioorg Med Chem Lett 20: 3039-42 (2010) Article DOI: 10.1016/j.bmcl.2010.03.115 BindingDB Entry DOI: 10.7270/Q2000281
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