Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50443719
(CHEMBL3093871 | US9238658, 25)Show SMILES OCc1csc(NC(=O)N2CCC(CC2)N2CCc3ccc(F)cc23)n1 Show InChI InChI=1S/C18H21FN4O2S/c19-13-2-1-12-3-8-23(16(12)9-13)15-4-6-22(7-5-15)18(25)21-17-20-14(10-24)11-26-17/h1-2,9,11,15,24H,3-8,10H2,(H,20,21,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation |
Bioorg Med Chem Lett 23: 6773-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.096
BindingDB Entry DOI: 10.7270/Q21J9C7J |
More data for this
Ligand-Target Pair | |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50443719
(CHEMBL3093871 | US9238658, 25)Show SMILES OCc1csc(NC(=O)N2CCC(CC2)N2CCc3ccc(F)cc23)n1 Show InChI InChI=1S/C18H21FN4O2S/c19-13-2-1-12-3-8-23(16(12)9-13)15-4-6-22(7-5-15)18(25)21-17-20-14(10-24)11-26-17/h1-2,9,11,15,24H,3-8,10H2,(H,20,21,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac... |
US Patent US9238658 (2016)
BindingDB Entry DOI: 10.7270/Q2930S1D |
More data for this
Ligand-Target Pair | |