Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50064097
(CHEMBL37456 | {[(S)-4-(2,4-Difluoro-phenyl)-1-(2-p...)Show SMILES OP(O)(=O)CN[C@@H](CC#Cc1ccc(F)cc1F)C(=O)NCCc1ccccn1 Show InChI InChI=1S/C19H20F2N3O4P/c20-15-8-7-14(17(21)12-15)4-3-6-18(24-13-29(26,27)28)19(25)23-11-9-16-5-1-2-10-22-16/h1-2,5,7-8,10,12,18,24H,6,9,11,13H2,(H,23,25)(H2,26,27,28)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1). |
J Med Chem 41: 1513-23 (1998)
Article DOI: 10.1021/jm970787c BindingDB Entry DOI: 10.7270/Q2PV6M1M |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50064097
(CHEMBL37456 | {[(S)-4-(2,4-Difluoro-phenyl)-1-(2-p...)Show SMILES OP(O)(=O)CN[C@@H](CC#Cc1ccc(F)cc1F)C(=O)NCCc1ccccn1 Show InChI InChI=1S/C19H20F2N3O4P/c20-15-8-7-14(17(21)12-15)4-3-6-18(24-13-29(26,27)28)19(25)23-11-9-16-5-1-2-10-22-16/h1-2,5,7-8,10,12,18,24H,6,9,11,13H2,(H,23,25)(H2,26,27,28)/t18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharmaceuticals Corporation
Curated by ChEMBL
| Assay Description Inhibitory activity against neutral endopeptidase (NEP). |
J Med Chem 41: 1513-23 (1998)
Article DOI: 10.1021/jm970787c BindingDB Entry DOI: 10.7270/Q2PV6M1M |
More data for this Ligand-Target Pair | |