Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM4085
(2,3,8,9-tetrahydroxy-5-[(4-nitrophenyl)methyl]-5,6...)Show SMILES Oc1cc2n(Cc3ccc(cc3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O Show InChI InChI=1S/C20H14N2O7/c23-16-5-12-13-6-17(24)19(26)8-15(13)21(20(27)14(12)7-18(16)25)9-10-1-3-11(4-2-10)22(28)29/h1-8,23-26H,9H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description IC50 is the inhibitor concentration, which inhibits 50% of pp60c-src activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ... |
J Med Chem 37: 2224-31 (1994)
Article DOI: 10.1021/jm00040a015 BindingDB Entry DOI: 10.7270/Q27M0648 |
More data for this Ligand-Target Pair | |
NADPH oxidase 4
(Homo sapiens (Human)) | BDBM4085
(2,3,8,9-tetrahydroxy-5-[(4-nitrophenyl)methyl]-5,6...)Show SMILES Oc1cc2n(Cc3ccc(cc3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O Show InChI InChI=1S/C20H14N2O7/c23-16-5-12-13-6-17(24)19(26)8-15(13)21(20(27)14(12)7-18(16)25)9-10-1-3-11(4-2-10)22(28)29/h1-8,23-26H,9H2 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vichem Chemie Research Ltd.
Curated by ChEMBL
| Assay Description Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay |
J Med Chem 53: 6758-62 (2010)
Article DOI: 10.1021/jm1004368 BindingDB Entry DOI: 10.7270/Q2F18ZZ5 |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha
(Bos taurus (bovine)) | BDBM4085
(2,3,8,9-tetrahydroxy-5-[(4-nitrophenyl)methyl]-5,6...)Show SMILES Oc1cc2n(Cc3ccc(cc3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O Show InChI InChI=1S/C20H14N2O7/c23-16-5-12-13-6-17(24)19(26)8-15(13)21(20(27)14(12)7-18(16)25)9-10-1-3-11(4-2-10)22(28)29/h1-8,23-26H,9H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer
| Assay Description IC50 is the inhibitor concentration, which inhibits 50% of PKA activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] label... |
J Med Chem 37: 2224-31 (1994)
Article DOI: 10.1021/jm00040a015 BindingDB Entry DOI: 10.7270/Q27M0648 |
More data for this Ligand-Target Pair | |