Compile Data Set for Download or QSAR

Found 116 hits Enz. Inhib. hit(s) with Target = 'Interleukin-17A'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-17A (Homo sapiens (Human))	BDBM50582230 (CHEMBL5091495) Show SMILES CC(F)(F)CNC(=O)[C@@H](CC(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C1CC1)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578383 (CHEMBL4870813) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1nnc2ccc(cn12)C#N |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50582232 (CHEMBL5091603) Show SMILES COC[C@H](C(=O)NCC(F)(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C1CC1)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50582229 (CHEMBL5080633) Show SMILES CC(F)(F)CNC(=O)C(CC(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C1CC1)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50582227 (CHEMBL5081660) Show SMILES CNC(=O)[C@H](NC(=O)[C@@H](CC(F)(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C)C1CCC(F)(F)CC1)C(C)C |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50582231 (CHEMBL5092697) Show SMILES CC(F)(F)CNC(=O)[C@@H](CC(F)(F)F)c1ccc2[nH]c(nc2c1F)[C@@H](NC(=O)c1nonc1C1CC1)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50582228 (CHEMBL5077953) Show SMILES CCc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CCS(=O)(=O)CC)C(=O)N1CC(F)(F)C(F)(F)C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00018 BindingDB Entry DOI: 10.7270/Q2H41W9T
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578386 (CHEMBL4872143) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@@H](CC(F)F)c1cnc2ccc(F)cn12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578382 (CHEMBL4865978) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)(F)F)c1cnnn1CC(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578381 (CHEMBL4860574) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1cnnn1CC(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574356 (CHEMBL4845695) Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)F)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578384 (CHEMBL4850368) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2cnc(cn12)C#N |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50578385 (CHEMBL4851738) Show SMILES Cc1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1nc2c(F)c(ccc2[nH]1)[C@H](CC(F)F)c1nnc2ccc(F)cn12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00608 BindingDB Entry DOI: 10.7270/Q2PR80T6
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574357 (CHEMBL4855085) Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1nonc1C(F)(F)F)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574355 (CHEMBL4874078) Show SMILES COC[C@@H](N1C[C@H](NC1=O)C(F)(F)F)c1cnn2cc(nc2c1)[C@@H](NC(=O)c1conc1C1CC1)C1CCC(F)(F)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50581144 (CHEMBL5087050) Show SMILES CNC(=O)[C@H]1Cc2ccc(NC(=O)C(Cc3cc(ccc3Cl)-c3cccc(CCC(=O)N1)c3)NC(=O)c1ccnn1C)cc2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A (unknown origin) measured by FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00327 BindingDB Entry DOI: 10.7270/Q2639TMX
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574354 (CHEMBL4866932) Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C(F)(F)F)C2CCC(F)(F)CC2)C(=O)N1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574352 (CHEMBL4876088) Show SMILES FC(F)(F)[C@@H]1CN(Cc2cnn3cc(nc3c2)[C@@H](NC(=O)c2nonc2C2CC2)C2CCC(F)(F)CC2)C(=O)N1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50574353 (CHEMBL4860250) Show SMILES CC(C)c1nonc1C(=O)N[C@@H](C1CCC(F)(F)CC1)c1cn2ncc(CN3C[C@H](NC3=O)C(F)(F)F)cc2n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00470 BindingDB Entry DOI: 10.7270/Q208693Q
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50573258 (CHEMBL4869568) Show SMILES CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human IL-17A assessed as inhibition of IL-17A interaction with 1L-17RA by ELISA				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00217 BindingDB Entry DOI: 10.7270/Q24B353V
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419139 (BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O |r| Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419139 (BDBM50461078 | N-(4-ethylphenyl)-N- isobutyl-3- me...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@](C)(=N)=O |r| Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50581142 (CHEMBL3785600) Show SMILES Clc1ccccc1C[C@H](NC(=O)Cc1ccccc1)C(=O)Nc1ccc(C[C@H]2NC(=O)CC3(CCCC3)CC(=O)NCCCCCNC(=O)CNC2=O)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A (unknown origin) by ELISA II				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00327 BindingDB Entry DOI: 10.7270/Q2639TMX
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50581141 (CHEMBL5075374) Show SMILES FC(F)(C(=O)N[C@@H](Cc1ccccc1Cl)C(=O)Nc1ccc(CCNC(=O)CC2(CC(=O)N3CCCC3)CCCC2)cc1)c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A (unknown origin) by ELISA II				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00327 BindingDB Entry DOI: 10.7270/Q2639TMX
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419256 (N-(2,4-dimethylphenyl)-N- isobutyl-3-(S- methylsul...) Show SMILES CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H36N2O5S2/c1-18(2)16-27(23-8-6-19(3)14-20(23)4)34(29,30)22-7-9-24(25(15-22)33(5,26)28)32-17-21-10-12-31-13-11-21/h6-9,14-15,18,21,26H,10-13,16-17H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419252 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncn2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C24H31N5O3S2/c1-5-19-6-8-21(9-7-19)29(16-18(2)3)34(31,32)22-10-11-23(24(14-22)33(4,25)30)27-15-20-12-13-26-17-28-20/h6-14,17-18,25,27H,5,15-16H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461076 (CHEMBL4227214 | US10457637, Compound 124) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(CC)CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C27H41N3O4S2/c1-6-22-8-10-23(11-9-22)30(19-21(3)4)36(32,33)24-12-13-25(26(18-24)35(5,28)31)29-20-27(7-2)14-16-34-17-15-27/h8-13,18,21,28-29H,6-7,14-17,19-20H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419242 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C23H33N3O4S2/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419234 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCC3(COC3)C2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H35N3O4S2/c1-5-20-6-8-21(9-7-20)28(15-19(2)3)34(30,31)22-10-11-23(24(14-22)33(4,26)29)27-13-12-25(16-27)17-32-18-25/h6-11,14,19,26H,5,12-13,15-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419225 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CSC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C23H33N3O3S3/c1-5-18-6-8-20(9-7-18)26(14-17(2)3)32(28,29)21-10-11-22(23(12-21)31(4,24)27)25-13-19-15-30-16-19/h6-12,17,19,24-25H,5,13-16H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419218 (4-((((1R,5S,6S)-3- oxabicyclo[3.1.0]hexan-6- yl)me...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NC[C@H]2[C@@H]3COC[C@H]23)c(c1)S(C)(=N)=O |r| Show InChI InChI=1S/C25H35N3O4S2/c1-5-18-6-8-19(9-7-18)28(14-17(2)3)34(30,31)20-10-11-24(25(12-20)33(4,26)29)27-13-21-22-15-32-16-23(21)22/h6-12,17,21-23,26-27H,5,13-16H2,1-4H3/t21-,22-,23+,33?	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419214 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N2CCSCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C23H33N3O3S3/c1-5-19-6-8-20(9-7-19)26(17-18(2)3)32(28,29)21-10-11-22(23(16-21)31(4,24)27)25-12-14-30-15-13-25/h6-11,16,18,24H,5,12-15,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419189 (N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O |(2.28,-4.62,;3.61,-3.85,;3.61,-2.31,;2.28,-1.54,;2.28,,;3.61,.77,;4.94,,;4.94,-1.54,;3.61,2.31,;4.94,3.08,;6.28,2.31,;7.61,3.08,;6.28,.77,;2.28,3.08,;2.28,4.62,;2.68,1.59,;.94,2.31,;.94,.77,;-.39,,;-1.72,.77,;-3.06,,;-3.06,-1.54,;-4.39,-2.31,;-5.88,-1.91,;-6.28,-3.4,;-7.61,-4.17,;-4.79,-3.8,;-1.72,2.31,;-.39,3.08,;-3.06,3.08,;-4.39,2.31,;-3.83,4.41,;-2.29,4.41,)| Show InChI InChI=1S/C24H35N3O4S2/c1-5-18-6-8-20(9-7-18)27(16-17(2)3)33(30,31)22-10-11-23(24(14-22)32(4,25)29)26-15-19-12-21(28)13-19/h6-11,14,17,19,21,25-26,28H,5,12-13,15-16H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461069 (CHEMBL4228522 | US10457637, Compound 66) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(N)(=O)=O Show InChI InChI=1S/C24H34N2O6S2/c1-4-19-5-7-21(8-6-19)26(16-18(2)3)34(29,30)22-9-10-23(24(15-22)33(25,27)28)32-17-20-11-13-31-14-12-20/h5-10,15,18,20H,4,11-14,16-17H2,1-3H3,(H2,25,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461083 (CHEMBL4225889 | US10457637, Compound 62) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(F)CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H36FN3O4S2/c1-5-20-6-8-21(9-7-20)29(17-19(2)3)35(31,32)22-10-11-23(24(16-22)34(4,27)30)28-18-25(26)12-14-33-15-13-25/h6-11,16,19,27-28H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419192 (N-(4-ethylphenyl)-N- isobutyl-3-(S- methylsulfonim...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccncc2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H32N4O3S2/c1-5-20-6-8-22(9-7-20)29(18-19(2)3)34(31,32)23-10-11-24(25(16-23)33(4,26)30)28-17-21-12-14-27-15-13-21/h6-16,19,26,28H,5,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461075 (CHEMBL4225072 | US10457637, Compound 55) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2(C)CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-22(10-8-21)29(18-20(2)3)35(31,32)23-11-12-24(25(17-23)34(5,27)30)28-19-26(4)13-15-33-16-14-26/h7-12,17,20,27-28H,6,13-16,18-19H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461066 (CHEMBL4228566 | US10457637, Compound 53) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(N(C)CC2CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C26H39N3O4S2/c1-6-21-7-9-23(10-8-21)29(18-20(2)3)35(31,32)24-11-12-25(26(17-24)34(5,27)30)28(4)19-22-13-15-33-16-14-22/h7-12,17,20,22,27H,6,13-16,18-19H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461074 (CHEMBL4227729 | US10457637, Compound 52) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H37N3O4S2/c1-5-20-6-8-22(9-7-20)28(18-19(2)3)34(30,31)23-10-11-24(25(16-23)33(4,26)29)27-17-21-12-14-32-15-13-21/h6-11,16,19,21,26-27H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419162 (N-(4-ethylphenyl)-4-((4- fluorotetrahydro-2H-pyran...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2(F)CCOCC2)c(c1)S(C)(=N)=O Show InChI InChI=1S/C25H35FN2O5S2/c1-5-20-6-8-21(9-7-20)28(17-19(2)3)35(30,31)22-10-11-23(24(16-22)34(4,27)29)33-18-25(26)12-14-32-15-13-25/h6-11,16,19,27H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461063 (CHEMBL4226803 | US10457637, Compound 8) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)(=N)=O |r| Show InChI InChI=1S/C25H36N2O5S2/c1-5-20-6-8-22(9-7-20)27(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,26)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21,26H,5,12-15,17-18H2,1-4H3/t33-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461065 (CHEMBL4225020 | US10457637, Compound 18) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(=N)(=O)CC Show InChI InChI=1S/C26H38N2O5S2/c1-5-21-7-9-23(10-8-21)28(18-20(3)4)35(30,31)24-11-12-25(26(17-24)34(27,29)6-2)33-19-22-13-15-32-16-14-22/h7-12,17,20,22,27H,5-6,13-16,18-19H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419154 (N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)=O Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419155 (N-(4-ethylphenyl)-N- isobutyl-3-methanesulfinyl- 4...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)[S@@](C)=O |r| Show InChI InChI=1S/C25H35NO5S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)33(28,29)23-10-11-24(25(16-23)32(4)27)31-18-21-12-14-30-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3/t32-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419157 (N-(4-ethylphenyl)-3- hydroxymethyl-N-isobutyl- 4-(...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(SCC2CCOCC2)c(CO)c1 Show InChI InChI=1S/C25H35NO4S2/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50461068 (CHEMBL4228069 | US10457637, Compound 24) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O Show InChI InChI=1S/C25H35NO6S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)34(29,30)23-10-11-24(25(16-23)33(4,27)28)32-18-21-12-14-31-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50581145 (CHEMBL5079201) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A (unknown origin) measured by AlphaLISA assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00327 BindingDB Entry DOI: 10.7270/Q2639TMX
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50581146 (CHEMBL5069442) Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IL-17A (unknown origin) measured by AlphaLISA assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00327 BindingDB Entry DOI: 10.7270/Q2639TMX
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM50403297 (CHEMBL5288854) Show SMILES OC(=O)CN1C[C@@H](SC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O)c1ccccc1 Show InChI InChI=1S/C22H24N2O4S2/c25-20(26)13-24-12-19(16-9-5-2-6-10-16)30-14-17(22(24)28)23-21(27)18(29)11-15-7-3-1-4-8-15/h1-10,17-19,29H,11-14H2,(H,23,27)(H,25,26)/t17-,18-,19+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars		n/a	n/a	221	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The calpain inhibitory activity(I 50) was measured as ability to enter the platelet to inhibit calpain after cell lysis(assay 2)				Citation and Details
					More data for this Ligand-Target Pair
Interleukin-17A (Homo sapiens (Human))	BDBM419160 (N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1 Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair

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