Compile Data Set for Download or QSAR

Found 998 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [808-1132]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228759 (US9346810, 208) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1c(F)cc(cc1F)C(=O)N[C@H](CO)c1ccccc1 Show InChI InChI=1S/C26H26F2N6O2/c1-33(18-8-10-34(13-18)25-19-7-9-29-24(19)30-15-31-25)23-20(27)11-17(12-21(23)28)26(36)32-22(14-35)16-5-3-2-4-6-16/h2-7,9,11-12,15,18,22,35H,8,10,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,22-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228760 (US9346810, 209) Show SMILES COC[C@@H](NC(=O)c1cc(F)c(N(C)[C@@H]2CCN(C2)c2ncnc3[nH]ccc23)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H28F2N6O2/c1-34(19-9-11-35(14-19)26-20-8-10-30-25(20)31-16-32-26)24-21(28)12-18(13-22(24)29)27(36)33-23(15-37-2)17-6-4-3-5-7-17/h3-8,10,12-13,16,19,23H,9,11,14-15H2,1-2H3,(H,33,36)(H,30,31,32)/t19-,23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228761 (US9346810, 210) Show SMILES CCS(=O)(=O)Nc1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C18H23N7O2S/c1-3-28(26,27)23-13-4-5-16(20-10-13)24(2)14-7-9-25(11-14)18-15-6-8-19-17(15)21-12-22-18/h4-6,8,10,12,14,23H,3,7,9,11H2,1-2H3,(H,19,21,22)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228762 (US10369153, Compound 212 | US9346810, 212) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cn1 Show InChI InChI=1S/C22H22FN7O2S/c1-29(17-9-11-30(13-17)22-19-8-10-24-21(19)26-14-27-22)20-7-4-16(12-25-20)28-33(31,32)18-5-2-15(23)3-6-18/h2-8,10,12,14,17,28H,9,11,13H2,1H3,(H,24,26,27)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228694 (US10369153, Compound 236 | US9346810, 236) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C19H23N7O2S/c1-25(17-5-4-15(10-21-17)29(27,28)24-13-2-3-13)14-7-9-26(11-14)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-14,24H,2-3,7,9,11H2,1H3,(H,20,22,23)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228698 (US9346810, 241) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC[C@@H]1CCCO1 Show InChI InChI=1S/C21H27N7O3S/c1-27(15-7-9-28(13-15)21-18-6-8-22-20(18)24-14-25-21)19-5-4-17(12-23-19)32(29,30)26-11-16-3-2-10-31-16/h4-6,8,12,14-16,26H,2-3,7,9-11,13H2,1H3,(H,22,24,25)/t15-,16+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228699 (US10369153, Compound 242 | US9346810, 242) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1COC1 Show InChI InChI=1S/C19H23N7O3S/c1-25(17-3-2-15(8-21-17)30(27,28)24-13-10-29-11-13)14-5-7-26(9-14)19-16-4-6-20-18(16)22-12-23-19/h2-4,6,8,12-14,24H,5,7,9-11H2,1H3,(H,20,22,23)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228758 (US9346810, 204) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)N[C@@H]1[C@@H](O)Cc2ccccc12 Show InChI InChI=1S/C27H27FN6O2/c1-33(18-9-11-34(14-18)26-20-8-10-29-25(20)30-15-31-26)22-7-6-17(12-21(22)28)27(36)32-24-19-5-3-2-4-16(19)13-23(24)35/h2-8,10,12,15,18,23-24,35H,9,11,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,23+,24+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228661 (US10369153, Compound 1 | US9346810, 1) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC#N Show InChI InChI=1S/C14H16N6O/c1-19(12(21)2-5-15)10-4-7-20(8-10)14-11-3-6-16-13(11)17-9-18-14/h3,6,9-10H,2,4,7-8H2,1H3,(H,16,17,18)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228709 (US10369153, Compound 40 | US9346810, 40) Show SMILES C=CCN(C1CCCC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C18H25N5/c1-2-10-23(14-5-3-4-6-14)15-8-11-22(12-15)18-16-7-9-19-17(16)20-13-21-18/h2,7,9,13-15H,1,3-6,8,10-12H2,(H,19,20,21)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228710 (US10369153, Compound 41 | US9346810, 41) Show SMILES N#Cc1ccc(nc1)N(C1CC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C19H19N7/c20-9-13-1-4-17(22-10-13)26(14-2-3-14)15-6-8-25(11-15)19-16-5-7-21-18(16)23-12-24-19/h1,4-5,7,10,12,14-15H,2-3,6,8,11H2,(H,21,23,24)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228668 (US10369153, Compound 42 | US9346810, 42) Show SMILES COc1nc(ccc1C#N)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C18H19N7O/c1-24(15-4-3-12(9-19)18(23-15)26-2)13-6-8-25(10-13)17-14-5-7-20-16(14)21-11-22-17/h3-5,7,11,13H,6,8,10H2,1-2H3,(H,20,21,22)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228711 (US9346810, 46) Show SMILES N#Cc1ccc2N(CCc2c1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C19H18N6/c20-10-13-1-2-17-14(9-13)4-8-25(17)15-5-7-24(11-15)19-16-3-6-21-18(16)22-12-23-19/h1-3,6,9,12,15H,4-5,7-8,11H2,(H,21,22,23)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228645 (US10111875, Compound 47 | US10369153, Compound 47 ...) Show SMILES CNS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228712 (US10369153, Compound 48 | US9346810, 48) Show SMILES CCS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C13H19N5O2S/c1-3-21(19,20)17(2)10-5-7-18(8-10)13-11-4-6-14-12(11)15-9-16-13/h4,6,9-10H,3,5,7-8H2,1-2H3,(H,14,15,16)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228713 (US10369153, Compound 60 | US9346810, 60) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(nn1)C#N Show InChI InChI=1S/C16H16N8/c1-23(14-3-2-11(8-17)21-22-14)12-5-7-24(9-12)16-13-4-6-18-15(13)19-10-20-16/h2-4,6,10,12H,5,7,9H2,1H3,(H,18,19,20)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228714 (US10369153, Compound 61 | US9346810, 61) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O Show InChI InChI=1S/C17H20N6O2S/c1-22(15-4-3-13(9-19-15)26(2,24)25)12-6-8-23(10-12)17-14-5-7-18-16(14)20-11-21-17/h3-5,7,9,11-12H,6,8,10H2,1-2H3,(H,18,20,21)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228715 (US10369153, Compound 62 | US9346810, 62) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(nn1)C(F)(F)F Show InChI InChI=1S/C16H16F3N7/c1-25(13-3-2-12(23-24-13)16(17,18)19)10-5-7-26(8-10)15-11-4-6-20-14(11)21-9-22-15/h2-4,6,9-10H,5,7-8H2,1H3,(H,20,21,22)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228716 (US10369153, Compound 63 | US9346810, 63) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(Cl)n1 Show InChI InChI=1S/C15H16ClN7/c1-22(12-3-6-18-15(16)21-12)10-4-7-23(8-10)14-11-2-5-17-13(11)19-9-20-14/h2-3,5-6,9-10H,4,7-8H2,1H3,(H,17,19,20)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228717 (US10369153, Compound 64 | US9346810, 64) Show SMILES CN(CCC#N)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C14H18N6/c1-19(7-2-5-15)11-4-8-20(9-11)14-12-3-6-16-13(12)17-10-18-14/h3,6,10-11H,2,4,7-9H2,1H3,(H,16,17,18)/t11-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228718 (US10369153, Compound 66 | US9346810, 66) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(F)cn1 Show InChI InChI=1S/C16H17FN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228669 (US10369153, Compound 67 | US9346810, 67) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(Cl)cn1 Show InChI InChI=1S/C16H17ClN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228719 (US10369153, Compound 71 | US9346810, 71 | US934681...) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228720 (US10369153, Compound 73 | US9346810, 73) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1nc(Cl)cc(C)c1C#N Show InChI InChI=1S/C18H18ClN7/c1-11-7-15(19)24-18(14(11)8-20)25(2)12-4-6-26(9-12)17-13-3-5-21-16(13)22-10-23-17/h3,5,7,10,12H,4,6,9H2,1-2H3,(H,21,22,23)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228721 (US10369153, Compound 80 | US9346810, 80) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncnc2ccccc12 Show InChI InChI=1S/C19H19N7/c1-25(18-14-4-2-3-5-16(14)21-11-23-18)13-7-9-26(10-13)19-15-6-8-20-17(15)22-12-24-19/h2-6,8,11-13H,7,9-10H2,1H3,(H,20,22,24)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228722 (US9346810, 81) Show SMILES N#Cc1ccc(NC2CCN(C2)c2ncnc3[nH]ccc23)nc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228723 (US10369153, Compound 84 | US9346810, 84) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N Show InChI InChI=1S/C16H16N8/c1-23(14-8-19-11(6-17)7-20-14)12-3-5-24(9-12)16-13-2-4-18-15(13)21-10-22-16/h2,4,7-8,10,12H,3,5,9H2,1H3,(H,18,21,22)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228672 (US10369153, Compound 86 | US9346810, 86) Show SMILES COc1cc2ncnc(N(C)[C@@H]3CCN(C3)c3ncnc4[nH]ccc34)c2cc1OC Show InChI InChI=1S/C21H23N7O2/c1-27(20-15-8-17(29-2)18(30-3)9-16(15)23-11-25-20)13-5-7-28(10-13)21-14-4-6-22-19(14)24-12-26-21/h4,6,8-9,11-13H,5,7,10H2,1-3H3,(H,22,24,26)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228724 (US10369153, Compound 87 | US9346810, 87) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1nc(Cl)c(cc1F)C#N Show InChI InChI=1S/C17H15ClFN7/c1-25(17-13(19)6-10(7-20)14(18)24-17)11-3-5-26(8-11)16-12-2-4-21-15(12)22-9-23-16/h2,4,6,9,11H,3,5,8H2,1H3,(H,21,22,23)/t11-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228725 (US10369153, Compound 91 | US9346810, 91) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cccc(n1)C#N Show InChI InChI=1S/C17H17N7/c1-23(15-4-2-3-12(9-18)22-15)13-6-8-24(10-13)17-14-5-7-19-16(14)20-11-21-17/h2-5,7,11,13H,6,8,10H2,1H3,(H,19,20,21)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228719 (US10369153, Compound 71 | US9346810, 71 | US934681...) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228727 (US9346810, 93) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C1NC(=CS1)C#N |c:21| Show InChI InChI=1S/C15H17N7S/c1-21(15-20-10(6-16)8-23-15)11-3-5-22(7-11)14-12-2-4-17-13(12)18-9-19-14/h2,4,8-9,11,15,20H,3,5,7H2,1H3,(H,17,18,19)/t11-,15?/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228728 (US10111875, Compound 142 | US10369153, Compound 14...) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(Br)cn1 Show InChI InChI=1S/C15H16BrN7/c1-22(15-18-6-10(16)7-19-15)11-3-5-23(8-11)14-12-2-4-17-13(12)20-9-21-14/h2,4,6-7,9,11H,3,5,8H2,1H3,(H,17,20,21)/t11-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228729 (US10369153, Compound 98 | US9346810, 98) Show SMILES CCCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C19H21N7/c1-2-8-26(17-4-3-14(10-20)11-22-17)15-6-9-25(12-15)19-16-5-7-21-18(16)23-13-24-19/h3-5,7,11,13,15H,2,6,8-9,12H2,1H3,(H,21,23,24)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228730 (US10369153, Compound 99 | US9346810, 99) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(cc1Br)C#N Show InChI InChI=1S/C17H16BrN7/c1-24(17-14(18)6-11(7-19)8-21-17)12-3-5-25(9-12)16-13-2-4-20-15(13)22-10-23-16/h2,4,6,8,10,12H,3,5,9H2,1H3,(H,20,22,23)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228731 (US10369153, Compound 102 | US9346810, 102) Show SMILES CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228732 (US10369153, Compound 103 | US9346810, 103) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C#N Show InChI InChI=1S/C18H17FN6/c1-24(16-3-2-12(9-20)8-15(16)19)13-5-7-25(10-13)18-14-4-6-21-17(14)22-11-23-18/h2-4,6,8,11,13H,5,7,10H2,1H3,(H,21,22,23)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228673 (US10369153, Compound 104 | US9346810, 104) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N Show InChI InChI=1S/C18H18N6/c1-23(14-4-2-13(10-19)3-5-14)15-7-9-24(11-15)18-16-6-8-20-17(16)21-12-22-18/h2-6,8,12,15H,7,9,11H2,1H3,(H,20,21,22)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228733 (US10369153, Compound 111 | US9346810, 111) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c2ccccc12 Show InChI InChI=1S/C22H20N6/c1-27(20-7-6-15(12-23)17-4-2-3-5-18(17)20)16-9-11-28(13-16)22-19-8-10-24-21(19)25-14-26-22/h2-8,10,14,16H,9,11,13H2,1H3,(H,24,25,26)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228734 (US10369153, Compound 114 | US9346810, 114) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(Br)c1 Show InChI InChI=1S/C18H17BrN6/c1-24(13-3-2-12(9-20)16(19)8-13)14-5-7-25(10-14)18-15-4-6-21-17(15)22-11-23-18/h2-4,6,8,11,14H,5,7,10H2,1H3,(H,21,22,23)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228676 (US10369153, Compound 121 | US9346810, 121) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(c1)C#N Show InChI InChI=1S/C17H17N7/c1-23(13-2-5-19-12(8-13)9-18)14-4-7-24(10-14)17-15-3-6-20-16(15)21-11-22-17/h2-3,5-6,8,11,14H,4,7,10H2,1H3,(H,20,21,22)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228677 (US10369153, Compound 122 | US9346810, 122) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C18H18F3N5O2S/c1-25(12-2-4-14(5-3-12)29(27,28)18(19,20)21)13-7-9-26(10-13)17-15-6-8-22-16(15)23-11-24-17/h2-6,8,11,13H,7,9-10H2,1H3,(H,22,23,24)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228678 (US10369153, Compound 123 | US9346810, 123) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(F)(F)F Show InChI InChI=1S/C17H17F3N6/c1-25(14-3-2-11(8-22-14)17(18,19)20)12-5-7-26(9-12)16-13-4-6-21-15(13)23-10-24-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,21,23,24)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228679 (US10369153, Compound 124 | US9346810, 124) Show SMILES N#Cc1ccc(nc1)N(CC1CC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C20H21N7/c21-9-15-3-4-18(23-10-15)27(11-14-1-2-14)16-6-8-26(12-16)20-17-5-7-22-19(17)24-13-25-20/h3-5,7,10,13-14,16H,1-2,6,8,11-12H2,(H,22,24,25)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228680 (US9346810, 125) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc2cn[nH]c2cn1 Show InChI InChI=1S/C17H18N8/c1-24(15-6-11-7-22-23-14(11)8-19-15)12-3-5-25(9-12)17-13-2-4-18-16(13)20-10-21-17/h2,4,6-8,10,12H,3,5,9H2,1H3,(H,22,23)(H,18,20,21)/t12-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228735 (US9346810, 126) Show SMILES CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C18H19N7/c1-2-25(16-4-3-13(9-19)10-21-16)14-6-8-24(11-14)18-15-5-7-20-17(15)22-12-23-18/h3-5,7,10,12,14H,2,6,8,11H2,1H3,(H,20,22,23)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228682 (US10369153, Compound 128 | US9346810, 128) Show SMILES C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N Show InChI InChI=1S/C19H17N7/c1-2-8-26(17-4-3-14(10-20)11-22-17)15-6-9-25(12-15)19-16-5-7-21-18(16)23-13-24-19/h1,3-5,7,11,13,15H,6,8-9,12H2,(H,21,23,24)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228736 (US10369153, Compound 129 | US9346810, 129) Show SMILES Fc1cc(cc(F)c1N(CC#C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C#N Show InChI InChI=1S/C20H16F2N6/c1-2-6-28(18-16(21)8-13(10-23)9-17(18)22)14-4-7-27(11-14)20-15-3-5-24-19(15)25-12-26-20/h1,3,5,8-9,12,14H,4,6-7,11H2,(H,24,25,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228737 (US10369153, Compound 131 | US9346810, 131) Show SMILES C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N Show InChI InChI=1S/C20H18N6/c1-2-10-26(16-5-3-15(12-21)4-6-16)17-8-11-25(13-17)20-18-7-9-22-19(18)23-14-24-20/h1,3-7,9,14,17H,8,10-11,13H2,(H,22,23,24)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM228738 (US9346810, 134) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)N1CCOCC1 Show InChI InChI=1S/C19H24N8O/c1-25(16-10-22-17(11-21-16)26-6-8-28-9-7-26)14-3-5-27(12-14)19-15-2-4-20-18(15)23-13-24-19/h2,4,10-11,13-14H,3,5-9,12H2,1H3,(H,20,23,24)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair

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