Found 5 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit beta-2' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-dependent L-type calcium channel subunit beta-2
(BOVINE) | BDBM86757
(CAS_0 | NSC_11603174 | [11C]MMP)Show InChI InChI=1S/C19H27N5O3/c1-21-18(25)15-20-24(19(21)26)10-6-5-9-22-11-13-23(14-12-22)16-7-3-4-8-17(16)27-2/h3-4,7-8,15H,5-6,9-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University
Curated by PDSP Ki Database
| |
Eur J Nucl Med Mol Imaging 34: 1050-60 (2007)
Article DOI: 10.1007/s00259-006-0324-y
BindingDB Entry DOI: 10.7270/Q2D7990W |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-2
(Homo sapiens) | BDBM50101971
(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C |c:7,12| Show InChI InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00458
BindingDB Entry DOI: 10.7270/Q2ZP4B6J |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-2
(Homo sapiens) | BDBM50602415
(CHEMBL5190568)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1C)C(=O)NCc1ccc(C)nc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01208
BindingDB Entry DOI: 10.7270/Q2MC943D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-2
(Homo sapiens) | BDBM50573712
(CHEBI:66722 | CHEMBL71260) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as time course of inhibition of membrane potential measured... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c00136
BindingDB Entry DOI: 10.7270/Q2HD80GQ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit beta-2
(Homo sapiens) | BDBM50573711
(CHEMBL4874732)Show SMILES [#6]-[#6](-[#6])[Si;v4](C#CC#C[#6@H](-[#8])-c1ccccc1)([#6](-[#6])-[#6])[#6](-[#6])-[#6] |r| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as time course of inhibition of membrane potential measured... |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.1c00136
BindingDB Entry DOI: 10.7270/Q2HD80GQ |
More data for this
Ligand-Target Pair | |
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