Found 313 hits Enz. Inhib. hit(s) with Target = 'Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631495
![PNG](/data/jpeg/tenK63/BindingDB_631495.png) (US20230348424, Example 78)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CN(C1)C(=O)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631686
![PNG](/data/jpeg/tenK63/BindingDB_631686.png) (US20230348424, Example 269)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(C)CCN(C1)C(=O)C1(F)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 1.21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631683
![PNG](/data/jpeg/tenK63/BindingDB_631683.png) (1-((S)-1-acetyl-3-methylpyrrolidin-3-yl)-N-((R)-1-...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(C)CCN(C1)C(C)=O)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631687
![PNG](/data/jpeg/tenK63/BindingDB_631687.png) (US20230348424, Example 270)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)C1(C)CN(C1)C(=O)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 1.74 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631681
![PNG](/data/jpeg/tenK63/BindingDB_631681.png) (US20230348424, Example 264)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CCN(C1)C(C)=O)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631684
![PNG](/data/jpeg/tenK63/BindingDB_631684.png) (US20230348424, Example 267)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CCN(C1)C(=O)C1(F)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 2.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631543
![PNG](/data/jpeg/tenK63/BindingDB_631543.png) (US20230348424, Example 126 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631615
![PNG](/data/jpeg/tenK63/BindingDB_631615.png) (US20230348424, Example 198)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2[C@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3.41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631526
![PNG](/data/jpeg/tenK63/BindingDB_631526.png) (US20230348424, Example 109 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2[C@@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631621
![PNG](/data/jpeg/tenK63/BindingDB_631621.png) (US20230348424, Example 204)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3.61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631496
![PNG](/data/jpeg/tenK63/BindingDB_631496.png) (: N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631559
![PNG](/data/jpeg/tenK63/BindingDB_631559.png) (US20230348424, Example 142 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631561
![PNG](/data/jpeg/tenK63/BindingDB_631561.png) (US20230348424, Example 144 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631627
![PNG](/data/jpeg/tenK63/BindingDB_631627.png) (US20230348424, Example 210)Show SMILES C[C@@H](NC(=O)c1cn(C2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CC[C@@H]1CN(C)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631543
![PNG](/data/jpeg/tenK63/BindingDB_631543.png) (US20230348424, Example 126 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631464
![PNG](/data/jpeg/tenK63/BindingDB_631464.png) (N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@@]1(C)CCOC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631620
![PNG](/data/jpeg/tenK63/BindingDB_631620.png) (US20230348424, Example 203)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631490
![PNG](/data/jpeg/tenK63/BindingDB_631490.png) (1-((1R,2S)-[1,1′-bi(cyclopropan)]-2-yl)-N-((...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631702
![PNG](/data/jpeg/tenK63/BindingDB_631702.png) (US20230348424, Example 285)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@@]12C[C@@H]1COC2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631649
![PNG](/data/jpeg/tenK63/BindingDB_631649.png) (US20230348424, Example 232 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631559
![PNG](/data/jpeg/tenK63/BindingDB_631559.png) (US20230348424, Example 142 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631724
![PNG](/data/jpeg/tenK63/BindingDB_631724.png) (N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC(C)(C)C2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631563
![PNG](/data/jpeg/tenK63/BindingDB_631563.png) (US20230348424, Example 146 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1NCC1(F)CN(C)C1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631612
![PNG](/data/jpeg/tenK63/BindingDB_631612.png) (US20230348424, Example 195)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2[C@@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(C)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 5.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631520
![PNG](/data/jpeg/tenK63/BindingDB_631520.png) (US20230348424, Example 103 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631553
![PNG](/data/jpeg/tenK63/BindingDB_631553.png) (US20230348424, Example 136 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1[C@H]2CC[C@@H]1CN(C)C2)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631600
![PNG](/data/jpeg/tenK63/BindingDB_631600.png) (N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCCn2cncc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631660
![PNG](/data/jpeg/tenK63/BindingDB_631660.png) (US20230348424, Example 243 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1N[C@@H]1[C@H]2C[C@@H]1CN(C)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631561
![PNG](/data/jpeg/tenK63/BindingDB_631561.png) (US20230348424, Example 144 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631568
![PNG](/data/jpeg/tenK63/BindingDB_631568.png) (US20230348424, Example 151 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]1(C)CCOC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631634
![PNG](/data/jpeg/tenK63/BindingDB_631634.png) ((R)-1- (bicyclo[1.1.1]pentan-1- yl)-N-(1-(3- (difl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631458
![PNG](/data/jpeg/tenK63/BindingDB_631458.png) (: (R)-N-(1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CCOCC2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631709
![PNG](/data/jpeg/tenK63/BindingDB_631709.png) (US20230348424, Example 292)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@]1(CCOC1)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631545
![PNG](/data/jpeg/tenK63/BindingDB_631545.png) (N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631524
![PNG](/data/jpeg/tenK63/BindingDB_631524.png) (N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(CC3)C2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631534
![PNG](/data/jpeg/tenK63/BindingDB_631534.png) (US20230348424, Example 117 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CC22CCC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631551
![PNG](/data/jpeg/tenK63/BindingDB_631551.png) (US20230348424, Example 134 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1[C@H]2CC[C@@H]1CN(C)C2)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631707
![PNG](/data/jpeg/tenK63/BindingDB_631707.png) (: 1-((1S,5S)-3-oxabicyclo[3.1.0]hexan-1-yl)-N-((R)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]12C[C@@H]1COC2)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631651
![PNG](/data/jpeg/tenK63/BindingDB_631651.png) (US20230348424, Example 234 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631624
![PNG](/data/jpeg/tenK63/BindingDB_631624.png) (1-cyclobutyl-N-((R)-1-(2- fluoro-3- (trifluorometh...)Show SMILES C[C@@H](NC(=O)c1cn(C2CCC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631694
![PNG](/data/jpeg/tenK63/BindingDB_631694.png) (US20230348424, Example 277 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCNC2(CC2)C1)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631728
![PNG](/data/jpeg/tenK63/BindingDB_631728.png) (N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CCN(C)C2(CC2)C1)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631489
![PNG](/data/jpeg/tenK63/BindingDB_631489.png) (1-((1S,2R)-[1,1′-bi(cyclopropan)]-2-yl)-N-((...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631704
![PNG](/data/jpeg/tenK63/BindingDB_631704.png) (US20230348424, Example 287)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]12C[C@@H]1COC2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631616
![PNG](/data/jpeg/tenK63/BindingDB_631616.png) (US20230348424, Example 199)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631648
![PNG](/data/jpeg/tenK63/BindingDB_631648.png) (N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631501
![PNG](/data/jpeg/tenK63/BindingDB_631501.png) (N-((R)-1-(3-(difluoromethyl)- 2-fluorophenyl)ethyl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CN2CCC1CC2)C1(CC1)C(F)F)c1cccc(C(F)F)c1F |wD:13.13,1.0,(-3.33,1.16,;-2,1.92,;-.67,1.16,;-.67,-.38,;-2,-1.16,;.67,-1.16,;2,-.38,;3.33,-1.16,;3.33,-2.7,;4.67,-3.46,;2,-3.46,;.67,-2.7,;-.67,-3.46,;-.67,-5,;.67,-5.77,;.67,-7.31,;-.67,-8.08,;-2,-7.31,;-2,-5.77,;-.75,-5.79,;-.39,-7.17,;4.67,-.38,;6,-1.15,;6,.39,;3.58,.7,;4.35,2.04,;2.09,.31,;-2,3.46,;-.67,4.24,;-.67,5.78,;-2,6.54,;-3.33,5.78,;-4.67,6.54,;-4.67,8.08,;-6,5.78,;-3.33,4.24,;-4.67,3.46,)| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631549
![PNG](/data/jpeg/tenK63/BindingDB_631549.png) (1-(bicyclo[2.2.1]heptan-1- yl)-N-((R)-1-(3- (diflu...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)C12CCC(CC1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631675
![PNG](/data/jpeg/tenK63/BindingDB_631675.png) (US20230348424, Example 258 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC(F)(F)C2)c(=O)cc1N[C@H]1[C@H]2CC[C@@H]1CN(C)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631730
![PNG](/data/jpeg/tenK63/BindingDB_631730.png) (US20230348424, Example 313)Show SMILES CCC12CC(C1)(C2)n1cc(C(=O)N[C@H](C)c2cccc(C(F)F)c2F)c(N[C@@H]2[C@H]3CN(C)C[C@@H]23)cc1=O | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |