Compile Data Set for Download or QSAR

Found 336 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)(E76K)'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488484 (US10954243, Example 15) Show SMILES CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1CF Show InChI InChI=1S/C18H19Cl2FN6/c1-18(22)5-7-27(8-6-18)17-12(9-21)23-15-14(25-26-16(15)24-17)10-3-2-4-11(19)13(10)20/h2-4H,5-9,22H2,1H3,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384120 (1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- py...) Show SMILES CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384120 (1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- py...) Show SMILES CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384120 (1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- py...) Show SMILES CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516932 (US11104675, Example 18a | US11104675, Example 18b) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Cc4ccn(C)n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N |r,wD:34.39,1.0,(7.32,-3.67,;5.79,-3.83,;5.02,-5.16,;3.51,-4.84,;3.35,-3.31,;2.02,-4.08,;.68,-3.31,;.68,-1.77,;2.02,-1,;3.35,-1.77,;-.65,-1,;-1.98,-1.77,;-3.32,-1,;-4.65,-1.77,;-3.32,.54,;-4.65,1.31,;-5.99,.54,;-7.32,1.31,;-7.32,2.85,;-8.65,3.62,;-9.99,2.85,;-10.15,1.32,;-11.65,1,;-12.42,2.33,;-13.96,2.49,;-11.39,3.48,;-5.99,3.62,;-5.99,5.16,;-4.65,2.85,;-3.32,3.62,;-1.98,1.31,;-1.98,2.85,;-.65,.54,;.68,1.31,;4.76,-2.68,;5.08,-1.18,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488489 (US10954243, Example 20) Show SMILES CNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(CO)nc23)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488485 (US10954243, Example 16) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cccc(Cl)c4Cl)c3nc2CO)[C@@H]1N |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516935 (US11104675, Example 20b) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Oc4cc[nH]n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N |r,wD:33.38,1.0,(7.32,-3.67,;5.79,-3.83,;5.02,-5.16,;3.51,-4.84,;3.35,-3.31,;2.02,-4.08,;.68,-3.31,;.68,-1.77,;2.02,-1,;3.35,-1.77,;-.65,-1,;-1.98,-1.77,;-3.32,-1,;-4.65,-1.77,;-3.32,.54,;-4.65,1.31,;-5.99,.54,;-7.32,1.31,;-7.32,2.85,;-8.65,3.62,;-9.99,2.85,;-10.15,1.32,;-11.65,1,;-12.42,2.33,;-11.39,3.48,;-5.99,3.62,;-5.99,5.16,;-4.65,2.85,;-3.32,3.62,;-1.98,1.31,;-1.98,2.85,;-.65,.54,;.68,1.31,;4.76,-2.68,;5.08,-1.18,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488486 (US10954243, Example 17) Show SMILES CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(CO)nc23)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488488 (US10954243, Example 19) Show SMILES CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(Cl)nc23)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488487 (US10954243, Example 18) Show SMILES CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(C)nc23)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516934 (US11104675, Example 19b) Show SMILES CNC(=O)c1ccc(Oc2ccc(c(Cl)c2Cl)-n2c(C)nc(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)c(C)c2=O)cc1 |r,wD:30.32,28.29,(-15.32,-1.77,;-13.99,-1,;-13.99,.54,;-15.32,1.31,;-12.65,1.31,;-12.65,2.85,;-11.32,3.62,;-9.99,2.85,;-8.65,3.62,;-7.32,2.85,;-7.32,1.31,;-5.99,.54,;-4.65,1.31,;-4.65,2.85,;-3.32,3.62,;-5.99,3.62,;-5.99,5.16,;-3.32,.54,;-3.32,-1,;-4.65,-1.77,;-1.98,-1.77,;-.65,-1,;.68,-1.77,;.68,-3.31,;2.02,-4.08,;3.35,-3.31,;3.51,-4.84,;5.02,-5.16,;5.79,-3.83,;7.32,-3.67,;4.76,-2.68,;5.08,-1.18,;3.35,-1.77,;2.02,-1,;-.65,.54,;.68,1.31,;-1.98,1.31,;-1.98,2.85,;-9.99,1.31,;-11.32,.54,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488480 (US10954243, Example 11) Show SMILES CNc1nccc(-c2n[nH]c3nc(N4CCC(C)(N)CC4)c(CO)nc23)c1Cl Show InChI InChI=1S/C18H23ClN8O/c1-18(20)4-7-27(8-5-18)17-11(9-28)23-14-13(25-26-16(14)24-17)10-3-6-22-15(21-2)12(10)19/h3,6,28H,4-5,7-9,20H2,1-2H3,(H,21,22)(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488476 (US10954243, Example 7) Show SMILES CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1CO Show InChI InChI=1S/C18H20Cl2N6O/c1-18(21)5-7-26(8-6-18)17-12(9-27)22-15-14(24-25-16(15)23-17)10-3-2-4-11(19)13(10)20/h2-4,27H,5-9,21H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516921 (US11104675, Example 12a | US11104675, Example 12b) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Br)[C@@H]1N |r,wD:27.31,1.0,(7.32,-3.67,;5.79,-3.83,;5.02,-5.16,;3.51,-4.84,;3.35,-3.31,;2.02,-4.08,;.68,-3.31,;.68,-1.77,;2.02,-1,;3.35,-1.77,;-.65,-1,;-1.98,-1.77,;-3.32,-1,;-4.65,-1.77,;-3.32,.54,;-4.65,1.31,;-5.99,.54,;-7.32,1.31,;-7.32,2.85,;-5.99,3.62,;-5.99,5.16,;-4.65,2.85,;-3.32,3.62,;-1.98,1.31,;-1.98,2.85,;-.65,.54,;.68,1.31,;4.76,-2.68,;5.08,-1.18,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488483 (US10954243, Example 14) Show SMILES CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C(F)F Show InChI InChI=1S/C18H18Cl2F2N6/c1-18(23)5-7-28(8-6-18)17-14(15(21)22)24-13-12(26-27-16(13)25-17)9-3-2-4-10(19)11(9)20/h2-4,15H,5-8,23H2,1H3,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM497074 (US11001561, Compound 63 | US11001561, Compound 63a...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2C)[C@@H]1N |r,wD:27.31,1.0,(7.31,-3.02,;5.85,-3.49,;5.37,-4.96,;3.83,-4.96,;3.36,-3.49,;2.02,-4.26,;.69,-3.49,;.69,-1.95,;2.02,-1.18,;3.36,-1.95,;-.64,-1.18,;-.64,.36,;-1.98,1.13,;-1.98,2.67,;-3.31,.36,;-4.65,1.13,;-5.98,.36,;-7.31,1.13,;-7.31,2.67,;-5.98,3.44,;-5.98,4.98,;-4.65,2.67,;-3.31,3.44,;-3.31,-1.18,;-4.65,-1.95,;-1.98,-1.95,;-1.98,-3.49,;4.6,-2.59,;4.6,-1.05,)| Show InChI InChI=1S/C21H26Cl2N4O2/c1-12-19(26-9-7-21(8-10-26)11-29-13(2)18(21)24)25-14(3)27(20(12)28)16-6-4-5-15(22)17(16)23/h4-6,13,18H,7-11,24H2,1-3H3/t13-,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384163 ((R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384163 ((R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384163 ((R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384191 ((R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H...) Show SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384191 ((R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H...) Show SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384191 ((R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H...) Show SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516917 (US11104675, Example 9) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Cl)[C@@H]1N |r,wD:27.31,1.0,(7.32,-3.67,;5.79,-3.83,;5.02,-5.16,;3.51,-4.84,;3.35,-3.31,;2.02,-4.08,;.68,-3.31,;.68,-1.77,;2.02,-1,;3.35,-1.77,;-.65,-1,;-1.98,-1.77,;-3.32,-1,;-4.65,-1.77,;-3.32,.54,;-4.65,1.31,;-5.99,.54,;-7.32,1.31,;-7.32,2.85,;-5.99,3.62,;-5.99,5.16,;-4.65,2.85,;-3.32,3.62,;-1.98,1.31,;-1.98,2.85,;-.65,.54,;.68,1.31,;4.76,-2.68,;5.08,-1.18,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488491 ((6-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4ccnc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488470 (US10954243, Example 1) Show SMILES Cc1nc2c(n[nH]c2nc1N1CCC(C)(N)CC1)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C18H20Cl2N6/c1-10-17(26-8-6-18(2,21)7-9-26)23-16-15(22-10)14(24-25-16)11-4-3-5-12(19)13(11)20/h3-5H,6-9,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384147 ((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...) Show SMILES COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384147 ((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...) Show SMILES COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384147 ((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...) Show SMILES COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384206 ((2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl...) Show SMILES N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384206 ((2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl...) Show SMILES N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384206 ((2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl...) Show SMILES N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384152 ((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...) Show SMILES N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384152 ((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...) Show SMILES N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384152 ((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...) Show SMILES N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384141 ((1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384141 ((1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384141 ((1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,...) Show SMILES COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl Show InChI InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384207 ((1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyra...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384207 ((1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyra...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384207 ((1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyra...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384208 ((1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384208 ((1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384208 ((1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3...) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM488477 (US10954243, Example 8) Show SMILES CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C(N)=O Show InChI InChI=1S/C18H19Cl2N7O/c1-18(22)5-7-27(8-6-18)17-14(15(21)28)23-13-12(25-26-16(13)24-17)9-3-2-4-10(19)11(9)20/h2-4H,5-8,22H2,1H3,(H2,21,28)(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
NAVIRE PHARMA, INC. US Patent					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				US Patent US10954243 (2021) BindingDB Entry DOI: 10.7270/Q2S185KT
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM516929 (US11104675, Example 16a | US11104675, Example 16b) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Oc3ccn(C)n3)c(Cl)c2Cl)[C@@H]1N |r,wD:33.38,1.0,(7.32,-3.67,;5.79,-3.83,;5.02,-5.16,;3.51,-4.84,;3.35,-3.31,;2.02,-4.08,;.68,-3.31,;.68,-1.77,;2.02,-1,;3.35,-1.77,;-.65,-1,;-.65,.54,;-1.98,1.31,;-1.98,2.85,;-3.32,.54,;-3.32,-1,;-4.65,-1.77,;-1.98,-1.77,;-4.65,1.31,;-5.99,.54,;-7.32,1.31,;-7.32,2.85,;-8.65,3.62,;-9.99,2.85,;-10.15,1.32,;-11.65,1,;-12.42,2.33,;-13.96,2.49,;-11.39,3.48,;-5.99,3.62,;-5.99,5.16,;-4.65,2.85,;-3.32,3.62,;4.76,-2.68,;5.08,-1.18,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GQ71XC
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM475734 (8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...) Show SMILES N[C@H]1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				US Patent US10851110 (2020) BindingDB Entry DOI: 10.7270/Q2833W4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM576074 (8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo [3,4-b] pyra...) Show SMILES N[C@@H]1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2TB1B4T
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384177 (8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...) Show SMILES NC1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 [E76K] (Homo sapiens (Human))	BDBM384184 (4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-p...) Show SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl Show InChI InChI=1S/C18H23ClN8/c1-18(10-20)4-7-27(8-5-18)12-9-23-15-14(25-26-17(15)24-12)11-3-6-22-16(21-2)13(11)19/h3,6,9H,4-5,7-8,10,20H2,1-2H3,(H,21,22)(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation					Assay Description Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...				Bioorg Med Chem 15: 6649-58 (2007) BindingDB Entry DOI: 10.7270/Q2TH8Q0Z
					More data for this Ligand-Target Pair

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