Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [654-1073]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [654-1073] (Homo sapiens (Human))	BDBM15337 ((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...) Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 |r,c:6,14| Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Biochemistry 43: 6091-100 (2004) Article DOI: 10.1021/bi049868i BindingDB Entry DOI: 10.7270/Q2DR2SQM
					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [654-1073] (Homo sapiens (Human))	BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) Show SMILES CC(C)Cn1c2nc[nH]c2c(=O)n(C)c1=O Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	242	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...				Biochemistry 43: 6091-100 (2004) Article DOI: 10.1021/bi049868i BindingDB Entry DOI: 10.7270/Q2DR2SQM
					More data for this Ligand-Target Pair				3D Structure (crystal)