Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM188529 (2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM188529 (2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM50438863 (10-(4-Hydroxyphenyl)-2,4-dioxo-pyrimido[4,5-b]quin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM50438865 (2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM50438870 (8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mus musculus (Mouse)) | BDBM50438882 (10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.11E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
National Institutes of Health | Assay Description TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&... | ACS Chem Biol 11: 1925-33 (2016) Article DOI: 10.1021/acschembio.5b01047 BindingDB Entry DOI: 10.7270/Q2G15ZN9 | |||||||||||
More data for this Ligand-Target Pair |