Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-2 (Homo sapiens (Human)) | BDBM50229786 (5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-P...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at San Francisco Curated by ChEMBL | Assay Description Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction | Nature 450: 1001-1009 (2007) Article DOI: 10.1038/nature06526 BindingDB Entry DOI: 10.7270/Q24Q7VTV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649497 (US11891386, Compound ARI-083) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649500 (US11891386, Compound ARI-120) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649499 (US11891386, Compound ARI-118) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-23 receptor (Homo sapiens) | BDBM50459752 (CHEMBL4206167) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci£n Lilly S.A. Curated by ChEMBL | Assay Description Binding affinity to recombinant human flag/His-tagged IL-23R (1 to 353 residues) expressed in HEK293F cells assessed as disruption of biotinylated IL... | ACS Med Chem Lett 9: 912-916 (2018) Article DOI: 10.1021/acsmedchemlett.8b00255 BindingDB Entry DOI: 10.7270/Q25B054G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM128384 (US8802721, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Synta Pharmaceuticals Corp. US Patent | Assay Description Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe... | US Patent US8802721 (2014) BindingDB Entry DOI: 10.7270/Q2CN72M4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649495 (US11891386, Compound ARI-056) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Mus musculus) | BDBM50022815 ((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Ltd. Curated by ChEMBL | Assay Description The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA) | J Med Chem 38: 3361-7 (1995) BindingDB Entry DOI: 10.7270/Q27W6B79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-23 receptor (Homo sapiens) | BDBM50459752 (CHEMBL4206167) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci£n Lilly S.A. Curated by ChEMBL | Assay Description Binding affinity to recombinant human flag/His-tagged IL-23R (1 to 353 residues) expressed in HEK293F cells assessed as disruption of biotinylated IL... | ACS Med Chem Lett 9: 912-916 (2018) Article DOI: 10.1021/acsmedchemlett.8b00255 BindingDB Entry DOI: 10.7270/Q25B054G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649503 (US11891386, Compound ARI-148) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649487 (US11891386, Compound ARI-067) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM128386 (US8802721, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Synta Pharmaceuticals Corp. US Patent | Assay Description Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe... | US Patent US8802721 (2014) BindingDB Entry DOI: 10.7270/Q2CN72M4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM50575333 (CHEMBL4857063) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01403 BindingDB Entry DOI: 10.7270/Q2C82F4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412475 (5-ethyl-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412467 (N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649498 (US11891386, Compound ARI-090) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649489 (US11891386, Compound ARI-140) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412392 (5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1H-pyrazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412445 (N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412443 (5-bromo-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412441 (N-(5-(2-chloro-5- cyclopropoxyphenyl)pyridin-2-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412442 (5-chloro-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)t...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM50587599 (CHEMBL5087453 | US11661419, Example 53 | US2023028...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00619 BindingDB Entry DOI: 10.7270/Q2736VT6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412489 (N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412476 (N-(5-(5-ethyl-2-(3-methylisoxazol-5- yl)thiazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412479 (N-(5-(5-ethyl-2-(isoxazol-3- yl)thiazol-4-yl)pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649505 (US11891386, Compound ARI-049) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412440 (N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412447 (N-(5-(5-ethyl-2-(5-methylisoxazol-3- yl)thiazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412451 (5-bromo-N-(5-(2-chloro-5- cyclopropoxyphenyl)pyraz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412488 (5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412468 (5-fluoro-4-methyl-N-(5-(5-methyl-2- (5-methylisoxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412481 (5-chloro-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM50575331 (CHEMBL4868242) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01403 BindingDB Entry DOI: 10.7270/Q2C82F4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412387 (N-(2'-chloro-5'-(trifluoromethyl)- [1,1'-biphenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412377 (N-(5-(2-ethyl-5-(1-methyl-1H- pyrazol-4-yl)phenyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412432 (N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412384 (N-(5-(2-chloro-5-(5-methylthiazol-2- yl)phenyl)pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Mus musculus) | BDBM50422041 (GECLOSPORIN) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sandoz Pharma Ltd. Curated by ChEMBL | Assay Description The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA) | J Med Chem 38: 3361-7 (1995) BindingDB Entry DOI: 10.7270/Q27W6B79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412511 (N-(5-(2-chloro-5- isopropoxyphenyl)pyrazin-2-yl)-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412459 (N-(5-(2-chloro-5- isopropoxyphenyl)pyridin-2-yl)-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412446 (5-cyano-N-(5-(5-ethyl-2-(5- methylisoxazol-3-yl)th...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM50587592 (CHEMBL5090091 | US11661419, Example 7 | US20230280...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00619 BindingDB Entry DOI: 10.7270/Q2736VT6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-21 (Homo sapiens (Human)) | BDBM649502 (US11891386, Compound ARI-146) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM128385 (US8802721, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Synta Pharmaceuticals Corp. US Patent | Assay Description Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe... | US Patent US8802721 (2014) BindingDB Entry DOI: 10.7270/Q2CN72M4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412465 ((Z)-N-(5-(1-(4-bromophenyl)prop-1- en-1-yl)pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412432 (N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412483 (5-bromo-N-(5-(2-chloro-5-(1-methyl- 1H-pyrazol-4-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM50575332 (CHEMBL4869725) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01403 BindingDB Entry DOI: 10.7270/Q2C82F4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM412482 (N-(5-(2-chloro-5-(1-methyl-1H- pyrazol-4-yl)phenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
PRCL RESEARCH INC. US Patent | Assay Description Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti... | US Patent US10399967 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FRQ | |||||||||||
More data for this Ligand-Target Pair |
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