BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 548 hits Enz. Inhib. hit(s) with Target = 'Protein kinase C iota type'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50427363
PNG
(CHEMBL2326002)
Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r|
Show InChI InChI=1S/C20H24ClFN6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-13(21)9-14(22)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PKC zeta (unknown origin)

J Med Chem 56: 1799-810 (2013)


Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>8.33E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PKC zeta

Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50463484
PNG
(CHEMBL4248525)
Show SMILES CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1
Show InChI InChI=1S/C26H30N6O2S/c1-31-10-12-32(13-11-31)9-4-14-34-20-6-2-5-19(15-20)16-24(33)30-26-29-23(18-35-26)22-17-28-25-21(22)7-3-8-27-25/h2-3,5-8,15,17-18H,4,9-14,16H2,1H3,(H,27,28)(H,29,30,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PKCiota (unknown origin)

Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50463479
PNG
(CHEMBL4249925)
Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PKCiota (unknown origin)

Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PKC-iota

Bioorg Med Chem Lett 20: 6915-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.004
BindingDB Entry DOI: 10.7270/Q2GF0TQS
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50395892
PNG
(CHEMBL2163772)
Show SMILES Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C17H11NO3/c19-11-6-7-14-12(8-11)16-15(10-4-2-1-3-5-10)13(20)9-18-17(16)21-14/h1-9,19-20H
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of PKCiota

Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542127
PNG
(CHEMBL4635482)
Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542127
PNG
(CHEMBL4635482)
Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01803
BindingDB Entry DOI: 10.7270/Q2KD22XQ
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542123
PNG
(CHEMBL4636488)
Show SMILES C1CNC[C@H](C1)Nc1cc(cc2cnccc12)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542116
PNG
(CHEMBL4646995)
Show SMILES Nc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1
Show InChI InChI=1S/C20H22N4/c21-17-5-3-14(4-6-17)15-10-16-12-23-9-7-19(16)20(11-15)24-18-2-1-8-22-13-18/h3-7,9-12,18,22,24H,1-2,8,13,21H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542119
PNG
(CHEMBL4644939)
Show SMILES Oc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1
Show InChI InChI=1S/C20H21N3O/c24-18-5-3-14(4-6-18)15-10-16-12-22-9-7-19(16)20(11-15)23-17-2-1-8-21-13-17/h3-7,9-12,17,21,23-24H,1-2,8,13H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542128
PNG
(CHEMBL4636337)
Show SMILES Nc1ccc(c(F)c1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H22F2N4/c22-20-17(4-5-18(24)21(20)23)13-9-14-11-26-8-6-16(14)19(10-13)27-15-3-1-2-7-25-12-15/h4-6,8-11,15,25,27H,1-3,7,12,24H2/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.800n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542132
PNG
(CHEMBL4632523)
Show SMILES Nc1ccc(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C20H23N5/c21-20-5-4-14(12-24-20)15-9-16-11-23-8-6-18(16)19(10-15)25-17-3-1-2-7-22-13-17/h4-6,8-12,17,22,25H,1-3,7,13H2,(H2,21,24)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542133
PNG
(CHEMBL4643553)
Show SMILES Nc1ccc(c(F)n1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C20H22FN5/c21-20-17(4-5-19(22)26-20)13-9-14-11-24-8-6-16(14)18(10-13)25-15-3-1-2-7-23-12-15/h4-6,8-11,15,23,25H,1-3,7,12H2,(H2,22,26)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542129
PNG
(CHEMBL4637452)
Show SMILES Nc1cc(F)c(cc1F)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H22F2N4/c22-18-10-20(24)19(23)9-17(18)13-7-14-11-26-6-4-16(14)21(8-13)27-15-3-1-2-5-25-12-15/h4,6-11,15,25,27H,1-3,5,12,24H2/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542126
PNG
(CHEMBL4642166)
Show SMILES Nc1ccc(cc1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H24N4/c22-18-6-4-15(5-7-18)16-11-17-13-24-10-8-20(17)21(12-16)25-19-3-1-2-9-23-14-19/h4-8,10-13,19,23,25H,1-3,9,14,22H2/t19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35167
PNG
(indazole-benzimidazole, 3)
Show SMILES COc1cc(ccc1O)-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)21-5-3-4-19-25(21)28-26(27-19)24-18-8-6-16(14-20(18)29-30-24)17-7-9-22(33)23(15-17)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.26n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455611
PNG
(CHEMBL4212424)
Show SMILES COc1cc2CC(CF)NCc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C10H14N2O3S2/c1-2-3-12-6-8-4-7-5-9(17(11,13)14)15-10(7)16-8/h4-5,12H,2-3,6H2,1H3,(H2,11,13,14)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455569
PNG
(CHEMBL4202753)
Show SMILES COc1cc2CCNCc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C24H21N5O/c1-30-23-12-15-2-6-25-13-17(15)10-20(23)21-14-28-29-9-5-16(11-22(21)29)18-3-7-26-24-19(18)4-8-27-24/h3-5,7-12,14,25H,2,6,13H2,1H3,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542134
PNG
(CHEMBL4647780)
Show SMILES Nc1cc(F)c(cn1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C20H22FN5/c21-18-9-20(22)25-12-17(18)13-7-14-10-24-6-4-16(14)19(8-13)26-15-3-1-2-5-23-11-15/h4,6-10,12,15,23,26H,1-3,5,11H2,(H2,22,25)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455593
PNG
(CHEMBL4208685)
Show SMILES COc1cc2CC(C)NCc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C25H23N5O/c1-15-9-17-12-24(31-2)21(10-18(17)13-28-15)22-14-29-30-8-5-16(11-23(22)30)19-3-6-26-25-20(19)4-7-27-25/h3-8,10-12,14-15,28H,9,13H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542125
PNG
(CHEMBL4643470)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccccc1
Show InChI InChI=1S/C17H17N3/c18-7-9-20-17-11-14(13-4-2-1-3-5-13)10-15-12-19-8-6-16(15)17/h1-6,8,10-12,20H,7,9,18H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455592
PNG
(CHEMBL4206065)
Show SMILES COc1cc2CN(C)Cc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C24H21N5O/c1-28-13-16-9-20(23(30-2)11-17(16)14-28)21-12-27-29-8-5-15(10-22(21)29)18-3-6-25-24-19(18)4-7-26-24/h3-12H,13-14H2,1-2H3,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35173
PNG
(indazole-benzimidazole, 9)
Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(N)cc1
Show InChI InChI=1S/C25H25N7/c1-31-11-13-32(14-12-31)22-4-2-3-20-24(22)28-25(27-20)23-19-10-7-17(15-21(19)29-30-23)16-5-8-18(26)9-6-16/h2-10,15H,11-14,26H2,1H3,(H,27,28)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.18n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35168
PNG
(indazole-benzimidazole, 4)
Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(O)cc1
Show InChI InChI=1S/C25H24N6O/c1-30-11-13-31(14-12-30)22-4-2-3-20-24(22)27-25(26-20)23-19-10-7-17(15-21(19)28-29-23)16-5-8-18(32)9-6-16/h2-10,15,32H,11-14H2,1H3,(H,26,27)(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.60n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542121
PNG
(CHEMBL4641918)
Show SMILES C1CNCC(C1)Nc1cc(cc2cnccc12)-c1ccccc1
Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455602
PNG
(CHEMBL4216507)
Show SMILES COc1cc2CNCc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C23H19N5O/c1-29-22-10-16-12-24-11-15(16)8-19(22)20-13-27-28-7-4-14(9-21(20)28)17-2-5-25-23-18(17)3-6-26-23/h2-10,13,24H,11-12H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.5n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542130
PNG
(CHEMBL4632384)
Show SMILES C1CC[C@@H](CNC1)Nc1cc(cc2cnccc12)-c1ccccc1 |r|
Show InChI InChI=1S/C21H23N3/c1-2-6-16(7-3-1)17-12-18-14-23-11-9-20(18)21(13-17)24-19-8-4-5-10-22-15-19/h1-3,6-7,9,11-14,19,22,24H,4-5,8,10,15H2/t19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.70n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50455589
PNG
(CHEMBL4213984)
Show SMILES COc1cc2CNCc2cc1-n1cnc2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C23H19N5O/c1-29-22-10-16-12-24-11-15(16)9-21(22)28-13-27-19-3-2-14(8-20(19)28)17-4-6-25-23-18(17)5-7-26-23/h2-10,13,24H,11-12H2,1H3,(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-zeta expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50543625
PNG
(CHEMBL3732444)
Show SMILES C1CCc2c(C1)sc1nc(nc(N3CCNCC3)c21)-c1ccncc1
Show InChI InChI=1S/C19H21N5S/c1-2-4-15-14(3-1)16-18(24-11-9-21-10-12-24)22-17(23-19(16)25-15)13-5-7-20-8-6-13/h5-8,21H,1-4,9-12H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of recombinant full-length human aPKCzeta expressed in Sf21 insect cells using 5FAM-ERMRPRKRQGSVRRRV-NH2 as substrate in presence of ATP a...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115480
BindingDB Entry DOI: 10.7270/Q2HM5D1S
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542111
PNG
(CHEMBL4644763)
Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cnc4[nH]ccc4c3)c2c1 |r|
Show InChI InChI=1S/C20H18N4O/c1-2-16(25-17-4-5-21-11-17)8-18-14(1)9-22-12-19(18)15-7-13-3-6-23-20(13)24-10-15/h1-3,6-10,12,17,21H,4-5,11H2,(H,23,24)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01803
BindingDB Entry DOI: 10.7270/Q2KD22XQ
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542122
PNG
(CHEMBL4642061)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1
Show InChI InChI=1S/C22H24N4O/c1-15(27)25-19-6-4-16(5-7-19)17-11-18-13-24-10-8-21(18)22(12-17)26-20-3-2-9-23-14-20/h4-8,10-13,20,23,26H,2-3,9,14H2,1H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542111
PNG
(CHEMBL4644763)
Show SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cnc4[nH]ccc4c3)c2c1 |r|
Show InChI InChI=1S/C20H18N4O/c1-2-16(25-17-4-5-21-11-17)8-18-14(1)9-22-12-19(18)15-7-13-3-6-23-20(13)24-10-15/h1-3,6-10,12,17,21H,4-5,11H2,(H,23,24)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542131
PNG
(CHEMBL4634517)
Show SMILES Fc1cccc(F)c1-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H21F2N3/c22-18-5-3-6-19(23)21(18)14-10-15-12-25-9-7-17(15)20(11-14)26-16-4-1-2-8-24-13-16/h3,5-7,9-12,16,24,26H,1-2,4,8,13H2/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 16.7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human PKCiota using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35166
PNG
(indazole-benzimidazole, 1)
Show SMILES COc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)22-5-3-4-20-25(22)28-26(27-20)24-19-8-6-16(14-21(19)29-30-24)18-9-7-17(33)15-23(18)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35181
PNG
(indazole-benzimidazole, 17)
Show SMILES COc1cc(N)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C26H27N7O/c1-32-10-12-33(13-11-32)22-5-3-4-20-25(22)29-26(28-20)24-19-8-6-16(14-21(19)30-31-24)18-9-7-17(27)15-23(18)34-2/h3-9,14-15H,10-13,27H2,1-2H3,(H,28,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 23.3n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455566
PNG
(CHEMBL4208028)
Show SMILES COc1cc2CNCc2cc1-n1cnc2cnc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C22H18N6O/c1-29-21-7-14-10-23-9-13(14)6-20(21)28-12-27-18-11-26-17(8-19(18)28)15-2-4-24-22-16(15)3-5-25-22/h2-8,11-12,23H,9-10H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 31.6n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human PKCiota using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542100
PNG
(CHEMBL4645728)
Show SMILES Nc1ccc(cc1)-c1cncc2ccc(O[C@H]3CCNC3)cc12 |r|
Show InChI InChI=1S/C19H19N3O/c20-15-4-1-13(2-5-15)19-12-22-10-14-3-6-16(9-18(14)19)23-17-7-8-21-11-17/h1-6,9-10,12,17,21H,7-8,11,20H2/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542124
PNG
(CHEMBL4641607)
Show SMILES C1CNC[C@@H](C1)Nc1cc(cc2cnccc12)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3/c1-2-5-15(6-3-1)16-11-17-13-22-10-8-19(17)20(12-16)23-18-7-4-9-21-14-18/h1-3,5-6,8,10-13,18,21,23H,4,7,9,14H2/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50536679
PNG
(CHEMBL4568087)
Show SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r|
Show InChI InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assay

Bioorg Med Chem Lett 26: 4362-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.003
BindingDB Entry DOI: 10.7270/Q2NP27X5
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 39.4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human PKCzeta using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50536679
PNG
(CHEMBL4568087)
Show SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r|
Show InChI InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Merck and Co.

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant human PRKCZ expressed in baculovirus expression system by Z'-LYTE assay

Bioorg Med Chem Lett 26: 4362-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.003
BindingDB Entry DOI: 10.7270/Q2NP27X5
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542127
PNG
(CHEMBL4635482)
Show SMILES Nc1ccc(c(F)c1)-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 |r|
Show InChI InChI=1S/C21H23FN4/c22-20-11-16(23)4-5-18(20)14-9-15-12-25-8-6-19(15)21(10-14)26-17-3-1-2-7-24-13-17/h4-6,8-12,17,24,26H,1-3,7,13,23H2/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of PKCzeta in human THP1 cells assessed as reduction in LPS-induced TNFalpha production pre-incubated for 60 mins before LPS simulations f...

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455589
PNG
(CHEMBL4213984)
Show SMILES COc1cc2CNCc2cc1-n1cnc2ccc(cc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C23H19N5O/c1-29-22-10-16-12-24-11-15(16)9-21(22)28-13-27-19-3-2-14(8-20(19)28)17-4-6-25-23-18(17)5-7-26-23/h2-10,13,24H,11-12H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35176
PNG
(indazole-benzimidazole, 12)
Show SMILES COc1cc(ccc1N)-c1ccc2c(n[nH]c2c1)-c1nc2c(cccc2[nH]1)N1CCN(C)CC1
Show InChI InChI=1S/C26H27N7O/c1-32-10-12-33(13-11-32)22-5-3-4-20-25(22)29-26(28-20)24-18-8-6-16(14-21(18)30-31-24)17-7-9-19(27)23(15-17)34-2/h3-9,14-15H,10-13,27H2,1-2H3,(H,28,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 51.3n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM50542120
PNG
(CHEMBL4648006)
Show SMILES Oc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1
Show InChI InChI=1S/C20H21N3O/c24-20-6-2-1-5-18(20)14-10-15-12-22-9-7-17(15)19(11-14)23-16-4-3-8-21-13-16/h1-2,5-7,9-12,16,21,23-24H,3-4,8,13H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method

J Med Chem 63: 7143-7162 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00449
BindingDB Entry DOI: 10.7270/Q24T6NWX
More data for this
Ligand-Target Pair
Protein kinase C zeta type


(Homo sapiens (Human))		BDBM35175
PNG
(indazole-benzimidazole, 11)
Show SMILES CN1CCN(CC1)c1cccc2[nH]c(nc12)-c1n[nH]c2cc(ccc12)-c1ccc(N)c(F)c1
Show InChI InChI=1S/C25H24FN7/c1-32-9-11-33(12-10-32)22-4-2-3-20-24(22)29-25(28-20)23-17-7-5-16(14-21(17)30-31-23)15-6-8-19(27)18(26)13-15/h2-8,13-14H,9-12,27H2,1H3,(H,28,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 55.5n/an/an/an/a7.523



Pfizer



Assay Description
Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...

Bioorg Med Chem Lett 19: 908-11 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.105
BindingDB Entry DOI: 10.7270/Q2G73C1H
More data for this
Ligand-Target Pair
Protein kinase C iota type


(Homo sapiens (Human))		BDBM50455594
PNG
(CHEMBL4212934)
Show SMILES COc1cc2CNCc2cc1-n1cnc2ccc(nc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C22H18N6O/c1-29-20-9-14-11-23-10-13(14)8-19(20)28-12-26-18-3-2-17(27-22(18)28)15-4-6-24-21-16(15)5-7-25-21/h2-9,12,23H,10-11H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...

J Med Chem 61: 4386-4396 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00060
BindingDB Entry DOI: 10.7270/Q2V69N5Z
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 548 total )  |  Next  |  Last  >>
Jump to: