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Compile Data Set for Download or QSAR

Found 242 hits Enz. Inhib. hit(s) with Target = 'Elongin-B'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536252
PNG
((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Show SMILES CC(C)[C@H](C(=O)N1C[C@H](O)C[C@H]1C1=NO[C@@](C)(N1)c1ccc(Br)cc1)c1cc(C)no1 |r,t:13|
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n/an/a 62.8n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536223
PNG
((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(C)no1 |r,t:13|
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n/an/a 202n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536223
PNG
((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(C)no1 |r,t:13|
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n/an/a 418n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536284
PNG
((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cn(C)nn1 |r,t:13|
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n/an/a 418n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536198
PNG
(US11242344, Example 104.4)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)[C@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(C)no1 |r,t:13|
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n/an/a 422n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536277
PNG
(US11242344, Example 1001.2 | US11242344, Example 1...)
Show SMILES CC(C)[C@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)C(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(OCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)no1 |r,t:13|
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n/an/a 795n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50099062
PNG
(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r|
Show InChI InChI=1S/C24H32N4O4S/c1-14-20(33-13-26-14)17-8-6-16(7-9-17)11-25-22(31)19-10-18(30)12-28(19)23(32)21(24(3,4)5)27-15(2)29/h6-9,13,18-19,21,30H,10-12H2,1-5H3,(H,25,31)(H,27,29)/t18-,19+,21-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459896
PNG
(CHEMBL4226250)
Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)cc2)ncc1C1CC1)C(=O)C1CCC1 |r|
Show InChI InChI=1S/C56H79N9O9S/c1-38-49(75-37-60-38)41-16-14-39(15-17-41)33-58-52(68)47-32-44(66)35-65(47)54(70)50(56(2,3)4)62-48(67)36-73-30-10-28-71-26-6-7-27-72-29-11-31-74-45-22-20-43(21-23-45)61-55-59-34-46(40-18-19-40)51(63-55)57-24-9-25-64(5)53(69)42-12-8-13-42/h14-17,20-23,34,37,40,42,44,47,50,66H,6-13,18-19,24-33,35-36H2,1-5H3,(H,58,68)(H,62,67)(H2,57,59,61,63)/t44-,47+,50-/m1/s1
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Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536276
PNG
((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(3-methyl-1,2...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1nc(C)no1 |r,t:13|
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n/an/a 1.62E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536254
PNG
(US11242344, Example 113.4)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NO[C@@](C)(N1)c1ccc(Br)cc1)c1cc(C)no1 |r,t:13|
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n/an/a 2.28E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536210
PNG
(US11242344, Example 106.2 | US11242344, Example 10...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)[C@](C)(N1)c1ccc(cc1)-c1cccnc1C)c1cc(C)no1 |r,t:13|
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n/an/a 2.96E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536268
PNG
((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(O)no1 |r,t:13|
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n/an/a 4.35E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536183
PNG
(2-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-...)
Show SMILES CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C |r,t:25|
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n/an/a 4.68E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459898
PNG
(CHEMBL4227907)
Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)cc2)ncc1Br)C(=O)C1CCC1 |r|
Show InChI InChI=1S/C53H74BrN9O9S/c1-36-46(73-35-58-36)38-16-14-37(15-17-38)31-56-49(66)44-30-41(64)33-63(44)51(68)47(53(2,3)4)60-45(65)34-71-28-10-26-69-24-6-7-25-70-27-11-29-72-42-20-18-40(19-21-42)59-52-57-32-43(54)48(61-52)55-22-9-23-62(5)50(67)39-12-8-13-39/h14-21,32,35,39,41,44,47,64H,6-13,22-31,33-34H2,1-5H3,(H,56,66)(H,60,65)(H2,55,57,59,61)/t41-,44+,47-/m1/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536240
PNG
(1-Cyano-N-((2S)-1-((4R)-4-hydroxy-2-((S)-5-methyl-...)
Show SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C |r,c:17|
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n/an/a 4.97E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536206
PNG
(US11242344, Example 105.4)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)[C@](C)(N1)c1ccc(cc1)-c1cccnc1)c1cc(C)no1 |r,t:13|
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n/an/a 5.39E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459907
PNG
(CHEMBL4225691)
Show SMILES CC(C)[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r|
Show InChI InChI=1S/C52H72BrN9O9S/c1-35(2)46(51(67)62-32-41(63)29-44(62)49(65)55-30-37-13-15-38(16-14-37)47-36(3)57-34-72-47)59-45(64)33-70-27-9-25-68-23-5-6-24-69-26-10-28-71-42-19-17-40(18-20-42)58-52-56-31-43(53)48(60-52)54-21-8-22-61(4)50(66)39-11-7-12-39/h13-20,31,34-35,39,41,44,46,63H,5-12,21-30,32-33H2,1-4H3,(H,55,65)(H,59,64)(H2,54,56,58,60)/t41-,44+,46+/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536178
PNG
(N-((2S)-1-((4R)-4-Hydroxy-2-(5-methyl-5-(4-(4-meth...)
Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)CC1C1=NC(=O)C(C)(N1)c1ccc(cc1)-c1scnc1C)C(C)(C)C |r,t:14|
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n/an/a 6.17E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536291
PNG
((5S)-2-((4R)-1-(2-(3-((6-(2-((4-((3-Ethynylphenyl)...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOCC#CC#CCOc1cc(on1)[C@@H](C(C)C)C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C |r,t:57|
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n/an/a 6.25E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536297
PNG
(US11242344, Example 1004.4)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOCC#CC#CCOc1cc(on1)[C@H](C(C)C)C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C |r,t:57|
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n/an/a 6.25E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536250
PNG
((2R)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NO[C@](C)(N1)c1ccc(Br)cc1)c1cc(C)no1 |r,t:13|
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n/an/a 6.30E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536190
PNG
(US11242344, Example 103.4)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)[C@](C)(N1)c1ccc(Br)cc1)c1cc(C)no1 |r,t:13|
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n/an/a 6.73E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536259
PNG
(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@H]1C1=NN(c2ccccc2)C(C)(C)N1)c1cc(C)no1 |r,t:13|
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n/an/a 9.32E+3n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459913
PNG
(CHEMBL4227623)
Show SMILES CC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r|
Show InChI InChI=1S/C51H70BrN9O9S/c1-4-43(50(66)61-32-40(62)29-44(61)48(64)54-30-36-13-15-37(16-14-36)46-35(2)56-34-71-46)58-45(63)33-69-27-9-25-67-23-5-6-24-68-26-10-28-70-41-19-17-39(18-20-41)57-51-55-31-42(52)47(59-51)53-21-8-22-60(3)49(65)38-11-7-12-38/h13-20,31,34,38,40,43-44,62H,4-12,21-30,32-33H2,1-3H3,(H,54,64)(H,58,63)(H2,53,55,57,59)/t40-,43+,44+/m1/s1
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n/an/a 9.90E+3n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536271
PNG
(1-((2S,4R)-2-((R)-5-(2′-fluoro-[1,1′-b...)
Show SMILES CC(C)C(C(=O)N1C[C@@H](C[C@H]1C1=NOC(C)(N1)c1ccc(Br)cc1)O[Si](C)(C)C(C)(C)C)c1cc(C)no1 |r,t:12|
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n/an/a 1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536226
PNG
(US11242344, Example 108.2)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@](C)(N1)c1ccc(cc1)-c1cccc(=O)n1C)c1cc(C)no1 |r,t:13|
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n/an/a 1.10E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459906
PNG
(CHEMBL4226773)
Show SMILES CCC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r|
Show InChI InChI=1S/C52H72BrN9O9S/c1-4-11-44(51(67)62-33-41(63)30-45(62)49(65)55-31-37-14-16-38(17-15-37)47-36(2)57-35-72-47)59-46(64)34-70-28-9-26-68-24-5-6-25-69-27-10-29-71-42-20-18-40(19-21-42)58-52-56-32-43(53)48(60-52)54-22-8-23-61(3)50(66)39-12-7-13-39/h14-21,32,35,39,41,44-45,63H,4-13,22-31,33-34H2,1-3H3,(H,55,65)(H,59,64)(H2,54,56,58,60)/t41-,44+,45+/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536179
PNG
((5S)-2-((4R)-4-hydroxy-1-((S)-1-(methylsulfonyl)pi...)
Show SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H]1CCCCN1S(C)(=O)=O |r,c:17|
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n/an/a 1.67E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536275
PNG
(US11242344, Example 1001.1)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(OCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)no1 |r,t:13|
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n/an/a 1.69E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536215
PNG
((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccccc1)c1cc(C)no1 |r,t:13|
PDB
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n/an/a 1.73E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536231
PNG
((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC2(CCc3ccccc23)N1)c1cc(C)no1 |r,t:13|
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n/an/a 1.75E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536231
PNG
((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC2(CCc3ccccc23)N1)c1cc(C)no1 |r,t:13|
PDB
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n/an/a 1.76E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536239
PNG
((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)CC1C1=NOC2(CCCc3ccccc23)N1)c1cc(C)no1 |r,t:13|
PDB
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UniProtKB/SwissProt

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n/an/a 1.96E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536239
PNG
((2R)-1-((4R)-2-(3,4-dihydro-2H,4'H-spiro[naphthale...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)CC1C1=NOC2(CCCc3ccccc23)N1)c1cc(C)no1 |r,t:13|
PDB
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UniProtKB/SwissProt

B.MOAD
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n/an/a 1.99E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536232
PNG
((5S)-2-((4R)-4-Hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cnn(C)c1 |r,t:13|
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n/an/a 2.06E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536244
PNG
((5S)-2-((4R)-4-hydroxy-1-((methylsulfonyl)-L-proly...)
Show SMILES Cc1ncsc1-c1ccc(cc1)[C@]1(C)NC(=NC1=O)C1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1S(C)(=O)=O |r,c:17|
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n/an/a 2.33E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536218
PNG
(US11242344, Example 107.2 | US11242344, Example 10...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)C(C)(C)N1)c1cc(C)no1 |r,t:13|
PDB
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n/an/a 2.41E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor


(Homo sapiens (Human))		BDBM50459899
PNG
(CHEMBL4226398)
Show SMILES C[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r|
Show InChI InChI=1S/C50H68BrN9O9S/c1-34-45(70-33-55-34)37-14-12-36(13-15-37)29-53-47(63)43-28-40(61)31-60(43)48(64)35(2)56-44(62)32-68-26-8-24-66-22-4-5-23-67-25-9-27-69-41-18-16-39(17-19-41)57-50-54-30-42(51)46(58-50)52-20-7-21-59(3)49(65)38-10-6-11-38/h12-19,30,33,35,38,40,43,61H,4-11,20-29,31-32H2,1-3H3,(H,53,63)(H,56,62)(H2,52,54,57,58)/t35-,40+,43-/m0/s1
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UniProtKB/SwissProt

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n/an/a 2.50E+4n/an/an/an/an/an/a



Arvinas LLC

Curated by ChEMBL


Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled...

J Med Chem 61: 583-598 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536287
PNG
(US11242344, Example 1003.3)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)CCCOCCOc2cc(on2)[C@H](C(C)C)C(=O)N2C[C@H](O)C[C@H]2C2=NC(=O)[C@@](C)(N2)c2ccc(cc2)-c2scnc2C)cc1)c1ccccc1 |r,t:49|
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n/an/a 3.04E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536203
PNG
((R)-1-((2S,4R)-2-(5,5-dimethyl-4,5-dihydro-1,2,4-o...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(C)N1)c1cc(C)no1 |r,t:13|
PDB
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UniProtKB/SwissProt

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n/an/a 3.14E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536187
PNG
((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...)
Show SMILES CC(=O)N1CCCCC1C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C |r,t:19|
PDB
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n/an/a 3.29E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536215
PNG
((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-phenyl-4,5...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(C)(N1)c1ccccc1)c1cc(C)no1 |r,t:13|
PDB
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UniProtKB/SwissProt

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n/an/a 3.36E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536251
PNG
((2R)-1-((2S,4R)-2-(5-(4-bromophenyl)-5-(trifluorom...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(N1)(c1ccc(Br)cc1)C(F)(F)F)c1cc(C)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.44E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536268
PNG
((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(O)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.54E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536264
PNG
(1-((2S,4R)-2-(1-ethyl-5,5-dimethyl-4,5-dihydro-1H-...)
Show SMILES CCN1N=C(NC1(C)C)[C@@H]1C[C@@H](O)CN1C(=O)C(C(C)C)c1cc(C)no1 |r,c:3|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.07E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536180
PNG
(N-((2S)-1-((4R)-2-(5-(4-Bromophenyl)-5-methyl-4-ox...)
Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)CC1C1=NC(=O)C(C)(N1)c1ccc(cc1)B1OC(C)(C)C(C)(C)O1)C(C)(C)C |r,t:14|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.33E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536245
PNG
((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(N1)(c1ccccc1)c1ccccc1)c1cc(C)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.57E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536256
PNG
((2S)-1-((2S,4R)-4-Hydroxy-2-(5-phenyl-5-(trifluoro...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NO[C@@](N1)(c1ccccc1)C(F)(F)F)c1cc(C)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.70E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536267
PNG
(US11242344, Example 137.2)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NS(=O)(=O)CN1)c1cc(C)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.73E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))		BDBM536255
PNG
(1-((2S,4R)-2-(5,5-dimethyl-1-(2,2,2-trifluoroethyl...)
Show SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@H]1C1=NN(CC(F)(F)F)C(C)(C)N1)c1cc(C)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.82E+4n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
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