Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Homo sapiens (Human)) | BDBM162872 (US9056859, 72) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of Cav2.1 (unknown origin) | Bioorg Med Chem Lett 26: 2339-43 (2016) Article DOI: 10.1016/j.bmcl.2016.03.035 BindingDB Entry DOI: 10.7270/Q2668G3Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Homo sapiens (Human)) | BDBM50338167 ((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of P/Q-type Cav2.1 at -80 mV holding potential by tandard voltage-clamp electrophysiology assay | Bioorg Med Chem Lett 21: 1692-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.089 BindingDB Entry DOI: 10.7270/Q2736R6W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Homo sapiens (Human)) | BDBM50400564 (CHEMBL2206242) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at P/Q-type Cav2.1 expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp method | ACS Med Chem Lett 3: 985-990 (2012) Article DOI: 10.1021/ml3002083 BindingDB Entry DOI: 10.7270/Q2BC40P0 | |||||||||||
More data for this Ligand-Target Pair |