Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM50528810 (CHEMBL4580787) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Competitive irreversible inhibition of CDK16/cyclin Y (unknown origin) in presence of Km ATP | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126637 BindingDB Entry DOI: 10.7270/Q23F4T3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 17.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human CDK16/cyclin-Y using RB protein as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Curated by ChEMBL | Assay Description Inhibition of human CDK16/cyclin-Y using RB protein as substrate by [gamma-33P]-ATP assay | Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM50573929 (CHEMBL4848734) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human CDK16/cyclin-Y using RB protein as substrate incubated for 2 hrs by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00271 BindingDB Entry DOI: 10.7270/Q2ZG6X2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM50598717 (CHEMBL5193702 | US20230348487, Example LS 6-45) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00922 BindingDB Entry DOI: 10.7270/Q2H1361P | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM50466210 (CHEMBL4281048) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 292 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of recombinant GST-tagged inactive state of human CDK16 (108 to end residues)/cyclin Y (2 to end residues) | Eur J Med Chem 158: 896-916 (2018) Article DOI: 10.1016/j.ejmech.2018.09.025 BindingDB Entry DOI: 10.7270/Q2DJ5J9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Y/Cyclin-dependent kinase 16 (Homo sapiens (Human)) | BDBM50539904 (CHEMBL4647764) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of kinase tracer 236 binding to recombinant human N-terminal GST-tagged human CDK16 (107 to end residues)/Cyclin Y (2 to end residues) exp... | J Med Chem 63: 6708-6726 (2020) Article DOI: 10.1021/acs.jmedchem.9b01929 BindingDB Entry DOI: 10.7270/Q25M698Z | |||||||||||
More data for this Ligand-Target Pair |