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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily K member 3' AND taxid = 10116   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel subfamily K member 3


(Rattus norvegicus)
BDBM50505297
PNG
(CHEBI:681848 | Doxapram)
Show SMILES CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
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MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of rat TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
BindingDB Entry DOI: 10.7270/Q2TT4V7B
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Rattus norvegicus)
BDBM50350790
PNG
(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 4.10E+4n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of rat TASK1 expressed in African green monkey COS7 cells by outside-out patches based electrophysiology assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
BindingDB Entry DOI: 10.7270/Q2TT4V7B
More data for this
Ligand-Target Pair