Compile Data Set for Download or QSAR

Found 44 hits of ic50 for UniProtKB: P0AFI2   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518948 (CHEMBL4574863) Show SMILES COc1ccc2cc(F)nc(N3CCN(CC(O)CNc4cc(=O)oc5ccc(F)cc45)CC3)c2c1 Show InChI InChI=1S/C26H26F2N4O4/c1-35-19-4-2-16-10-24(28)30-26(20(16)12-19)32-8-6-31(7-9-32)15-18(33)14-29-22-13-25(34)36-23-5-3-17(27)11-21(22)23/h2-5,10-13,18,29,33H,6-9,14-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518940 (CHEMBL4541988) Show SMILES OC(CNc1nc(=O)oc2ccc(F)cc12)CN1CCN(CC1)c1nccc2ccc(F)cc12 Show InChI InChI=1S/C24H23F2N5O3/c25-16-2-1-15-5-6-27-23(19(15)11-16)31-9-7-30(8-10-31)14-18(32)13-28-22-20-12-17(26)3-4-21(20)34-24(33)29-22/h1-6,11-12,18,32H,7-10,13-14H2,(H,28,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518915 (CHEMBL4583368) Show SMILES OC(CNc1nc(=O)oc2ccc(F)cc12)CN1CCN(CC1)c1nc(F)cc2ccc(F)cc12 Show InChI InChI=1S/C24H22F3N5O3/c25-15-2-1-14-9-21(27)29-23(18(14)10-15)32-7-5-31(6-8-32)13-17(33)12-28-22-19-11-16(26)3-4-20(19)35-24(34)30-22/h1-4,9-11,17,33H,5-8,12-13H2,(H,28,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518924 (CHEMBL4533152) Show SMILES OC(CNc1cc(=O)oc2ccc(F)cc12)CN1CCN(CC1)c1nccc2ncccc12 Show InChI InChI=1S/C24H24FN5O3/c25-16-3-4-22-19(12-16)21(13-23(32)33-22)28-14-17(31)15-29-8-10-30(11-9-29)24-18-2-1-6-26-20(18)5-7-27-24/h1-7,12-13,17,28,31H,8-11,14-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518911 (CHEMBL4530328) Show SMILES O[C@H](CNc1nc(=O)oc2ccccc12)CN1CCN(CC1)c1nccc2ccc(F)cc12 |r| Show InChI InChI=1S/C24H24FN5O3/c25-17-6-5-16-7-8-26-23(20(16)13-17)30-11-9-29(10-12-30)15-18(31)14-27-22-19-3-1-2-4-21(19)33-24(32)28-22/h1-8,13,18,31H,9-12,14-15H2,(H,27,28,32)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518928 (CHEMBL4544202) Show SMILES Fc1ccc2ccnc(N3CCN(CCC(=O)Nc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C25H23FN4O3/c26-18-6-5-17-7-9-27-25(20(17)15-18)30-13-11-29(12-14-30)10-8-23(31)28-21-16-24(32)33-22-4-2-1-3-19(21)22/h1-7,9,15-16H,8,10-14H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518918 (CHEMBL4569403) Show SMILES COc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C26H28N4O3/c1-32-20-8-7-19-9-11-28-26(22(19)17-20)30-15-13-29(14-16-30)12-4-10-27-23-18-25(31)33-24-6-3-2-5-21(23)24/h2-3,5-9,11,17-18,27H,4,10,12-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518922 (CHEMBL4441397) Show SMILES O=c1cc(N[C@H]2C[C@H](C2)N2CCN(CC2)c2nccc3ccccc23)c2ccccc2o1 |r,wU:7.9,5.4,(23.93,-35.73,;22.38,-35.72,;21.61,-34.37,;20.07,-34.37,;19.31,-33.03,;17.76,-33.02,;16.66,-34.11,;15.57,-33.01,;16.67,-31.92,;14.02,-33.01,;13.25,-34.35,;11.71,-34.34,;10.93,-33,;11.71,-31.66,;13.26,-31.66,;9.39,-33,;8.62,-31.67,;7.07,-31.67,;6.31,-33.01,;7.09,-34.32,;6.31,-35.65,;7.08,-36.98,;8.62,-36.98,;9.38,-35.66,;8.62,-34.34,;19.3,-35.7,;17.76,-35.69,;16.98,-37.02,;17.75,-38.36,;19.28,-38.36,;20.05,-37.04,;21.6,-37.05,)| Show InChI InChI=1S/C26H26N4O2/c31-25-17-23(22-7-3-4-8-24(22)32-25)28-19-15-20(16-19)29-11-13-30(14-12-29)26-21-6-2-1-5-18(21)9-10-27-26/h1-10,17,19-20,28H,11-16H2/t19-,20+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518926 (CHEMBL4536608) Show SMILES O[C@@H](CNc1cc(=O)oc2ccccc12)CN1CCN(CC1)c1nccc2ccc(F)cc12 |r| Show InChI InChI=1S/C25H25FN4O3/c26-18-6-5-17-7-8-27-25(21(17)13-18)30-11-9-29(10-12-30)16-19(31)15-28-22-14-24(32)33-23-4-2-1-3-20(22)23/h1-8,13-14,19,28,31H,9-12,15-16H2/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518933 (CHEMBL4567626) Show SMILES Clc1ccc2oc(=O)cc(NCCCN3CCN(CC3)c3nccc4ccccc34)c2c1 Show InChI InChI=1S/C25H25ClN4O2/c26-19-6-7-23-21(16-19)22(17-24(31)32-23)27-9-3-11-29-12-14-30(15-13-29)25-20-5-2-1-4-18(20)8-10-28-25/h1-2,4-8,10,16-17,27H,3,9,11-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518932 (CHEMBL4467826) Show SMILES Fc1ccc2oc(=O)cc(NCCCN3CCN(CC3)c3nccc4ccccc34)c2c1 Show InChI InChI=1S/C25H25FN4O2/c26-19-6-7-23-21(16-19)22(17-24(31)32-23)27-9-3-11-29-12-14-30(15-13-29)25-20-5-2-1-4-18(20)8-10-28-25/h1-2,4-8,10,16-17,27H,3,9,11-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518941 (CHEMBL4465361) Show SMILES O[C@H](CNc1cc(=O)oc2ccccc12)CN1CCN(CC1)c1nccc2ccc(F)cc12 |r| Show InChI InChI=1S/C25H25FN4O3/c26-18-6-5-17-7-8-27-25(21(17)13-18)30-11-9-29(10-12-30)16-19(31)15-28-22-14-24(32)33-23-4-2-1-3-20(22)23/h1-8,13-14,19,28,31H,9-12,15-16H2/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518910 (CHEMBL4554663) Show SMILES O=c1cc(NCCCN2CCN(CC2)c2nccc3ccc(cc23)C#N)c2ccccc2o1 Show InChI InChI=1S/C26H25N5O2/c27-18-19-6-7-20-8-10-29-26(22(20)16-19)31-14-12-30(13-15-31)11-3-9-28-23-17-25(32)33-24-5-2-1-4-21(23)24/h1-2,4-8,10,16-17,28H,3,9,11-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518938 (CHEMBL4445613) Show SMILES Fc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C25H25FN4O2/c26-19-7-6-18-8-10-28-25(21(18)16-19)30-14-12-29(13-15-30)11-3-9-27-22-17-24(31)32-23-5-2-1-4-20(22)23/h1-2,4-8,10,16-17,27H,3,9,11-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518944 (CHEMBL4537564) Show SMILES Fc1cc2ccccc2c(n1)N1CCN(CCCNc2cc(=O)oc3ccccc23)CC1 Show InChI InChI=1S/C25H25FN4O2/c26-23-16-18-6-1-2-7-19(18)25(28-23)30-14-12-29(13-15-30)11-5-10-27-21-17-24(31)32-22-9-4-3-8-20(21)22/h1-4,6-9,16-17,27H,5,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50393503 (CHEMBL2158050) Show SMILES COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(CCSc4cccs4)C[C@@H]3C(O)=O)c2c1 |r| Show InChI InChI=1S/C25H29FN2O4S2/c1-32-17-5-6-21-18(13-17)24(20(26)14-27-21)22(29)7-4-16-8-9-28(15-19(16)25(30)31)10-12-34-23-3-2-11-33-23/h2-3,5-6,11,13-14,16,19,22,29H,4,7-10,12,15H2,1H3,(H,30,31)/t16-,19+,22+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 60 mins by eth...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518917 (CHEMBL4453182) Show SMILES Cc1c(NCCCN2CCN(CC2)c2nccc3ccc(F)cc23)c2ccccc2oc1=O Show InChI InChI=1S/C26H27FN4O2/c1-18-24(21-5-2-3-6-23(21)33-26(18)32)28-10-4-12-30-13-15-31(16-14-30)25-22-17-20(27)8-7-19(22)9-11-29-25/h2-3,5-9,11,17,28H,4,10,12-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518943 (CHEMBL4435611) Show SMILES COc1cc2ccccc2c(n1)N1CCN(CCCNc2cc(=O)oc3ccccc23)CC1 Show InChI InChI=1S/C26H28N4O3/c1-32-24-17-19-7-2-3-8-20(19)26(28-24)30-15-13-29(14-16-30)12-6-11-27-22-18-25(31)33-23-10-5-4-9-21(22)23/h2-5,7-10,17-18,27H,6,11-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518951 (CHEMBL4570423) Show SMILES Clc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C25H25ClN4O2/c26-19-7-6-18-8-10-28-25(21(18)16-19)30-14-12-29(13-15-30)11-3-9-27-22-17-24(31)32-23-5-2-1-4-20(22)23/h1-2,4-8,10,16-17,27H,3,9,11-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518925 (CHEMBL4438807) Show SMILES OC(CCN1CCN(CC1)c1nccc2ccc(F)cc12)Cc1cc(=O)oc2ccccc12 Show InChI InChI=1S/C26H26FN3O3/c27-20-6-5-18-7-9-28-26(23(18)17-20)30-13-11-29(12-14-30)10-8-21(31)15-19-16-25(32)33-24-4-2-1-3-22(19)24/h1-7,9,16-17,21,31H,8,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518927 (CHEMBL4549719) Show SMILES O=c1cc(N[C@H]2C[C@@H](C2)N2CCN(CC2)c2nccc3ccccc23)c2ccccc2o1 |r,wU:7.9,wD:5.4,(48.21,-35.72,;46.66,-35.71,;45.89,-34.36,;44.35,-34.36,;43.58,-33.02,;42.04,-33.01,;40.95,-31.91,;39.85,-33,;40.94,-34.09,;38.3,-33,;37.53,-34.33,;35.99,-34.33,;35.21,-32.99,;35.98,-31.65,;37.54,-31.65,;33.67,-32.99,;32.9,-31.65,;31.35,-31.66,;30.59,-32.99,;31.37,-34.31,;30.59,-35.64,;31.36,-36.97,;32.9,-36.97,;33.66,-35.64,;32.9,-34.33,;43.57,-35.69,;42.04,-35.68,;41.26,-37,;42.03,-38.34,;43.56,-38.35,;44.33,-37.03,;45.87,-37.04,)| Show InChI InChI=1S/C26H26N4O2/c31-25-17-23(22-7-3-4-8-24(22)32-25)28-19-15-20(16-19)29-11-13-30(14-12-29)26-21-6-2-1-5-18(21)9-10-27-26/h1-10,17,19-20,28H,11-16H2/t19-,20-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518920 (CHEMBL4465692) Show SMILES Cc1cccc2oc(=O)cc(NCCCN3CCN(CC3)c3nccc4ccc(F)cc34)c12 Show InChI InChI=1S/C26H27FN4O2/c1-18-4-2-5-23-25(18)22(17-24(32)33-23)28-9-3-11-30-12-14-31(15-13-30)26-21-16-20(27)7-6-19(21)8-10-29-26/h2,4-8,10,16-17,28H,3,9,11-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518936 (CHEMBL4538428) Show SMILES Clc1cc2ccccc2c(n1)N1CCN(CCCNc2cc(=O)oc3ccccc23)CC1 Show InChI InChI=1S/C25H25ClN4O2/c26-23-16-18-6-1-2-7-19(18)25(28-23)30-14-12-29(13-15-30)11-5-10-27-21-17-24(31)32-22-9-4-3-8-20(21)22/h1-4,6-9,16-17,27H,5,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518947 (CHEMBL4527338) Show SMILES Cc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C26H28N4O2/c1-19-7-8-20-9-11-28-26(22(20)17-19)30-15-13-29(14-16-30)12-4-10-27-23-18-25(31)32-24-6-3-2-5-21(23)24/h2-3,5-9,11,17-18,27H,4,10,12-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518935 (CHEMBL4591085) Show SMILES O=c1cc(NCCCN2CCN(CC2)c2nc(cc3ccccc23)C#N)c2ccccc2o1 Show InChI InChI=1S/C26H25N5O2/c27-18-20-16-19-6-1-2-7-21(19)26(29-20)31-14-12-30(13-15-31)11-5-10-28-23-17-25(32)33-24-9-4-3-8-22(23)24/h1-4,6-9,16-17,28H,5,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518923 (CHEMBL579300 | GNF-Pf-2217 | MMV665786) Show SMILES Clc1ccc2oc(=O)cc(NC3CCN(CCCc4ccccc4)CC3)c2c1 Show InChI InChI=1S/C23H25ClN2O2/c24-18-8-9-22-20(15-18)21(16-23(27)28-22)25-19-10-13-26(14-11-19)12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-9,15-16,19,25H,4,7,10-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518912 (CHEMBL4538641) Show SMILES O=c1cc(NCCN2CCN(CC2)c2nccc3ccccc23)c2ccccc2o1 Show InChI InChI=1S/C24H24N4O2/c29-23-17-21(20-7-3-4-8-22(20)30-23)25-11-12-27-13-15-28(16-14-27)24-19-6-2-1-5-18(19)9-10-26-24/h1-10,17,25H,11-16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518931 (CHEMBL4557243) Show SMILES Fc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5CCNCc45)CC3)c2c1 Show InChI InChI=1S/C24H28FN5O2/c25-18-3-2-17-4-8-28-24(19(17)14-18)30-12-10-29(11-13-30)9-1-6-27-21-15-23(31)32-22-5-7-26-16-20(21)22/h2-4,8,14-15,26-27H,1,5-7,9-13,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518946 (CHEMBL4548671) Show SMILES O=c1cc(NCCCN2CCN(CC2)c2nccc3ccccc23)c2CCCCc2o1 Show InChI InChI=1S/C25H30N4O2/c30-24-18-22(21-8-3-4-9-23(21)31-24)26-11-5-13-28-14-16-29(17-15-28)25-20-7-2-1-6-19(20)10-12-27-25/h1-2,6-7,10,12,18,26H,3-5,8-9,11,13-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518913 (CHEMBL4575351) Show SMILES Fc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5CCSCc45)CC3)c2c1 Show InChI InChI=1S/C24H27FN4O2S/c25-18-3-2-17-4-7-27-24(19(17)14-18)29-11-9-28(10-12-29)8-1-6-26-21-15-23(30)31-22-5-13-32-16-20(21)22/h2-4,7,14-15,26H,1,5-6,8-13,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518937 (CHEMBL4583024) Show SMILES CN(C)c1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5ccccc45)CC3)c2c1 Show InChI InChI=1S/C27H31N5O2/c1-30(2)21-9-8-20-10-12-29-27(23(20)18-21)32-16-14-31(15-17-32)13-5-11-28-24-19-26(33)34-25-7-4-3-6-22(24)25/h3-4,6-10,12,18-19,28H,5,11,13-17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518939 (CHEMBL4531900) Show SMILES O=c1cc(NCCCN2CCN(CC2)c2nccc3ccccc23)c2ccccc2o1 Show InChI InChI=1S/C25H26N4O2/c30-24-18-22(21-8-3-4-9-23(21)31-24)26-11-5-13-28-14-16-29(17-15-28)25-20-7-2-1-6-19(20)10-12-27-25/h1-4,6-10,12,18,26H,5,11,13-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518934 (CHEMBL4530941) Show SMILES Cc1cc2ccccc2c(n1)N1CCN(CCCNc2cc(=O)oc3ccccc23)CC1 Show InChI InChI=1S/C26H28N4O2/c1-19-17-20-7-2-3-8-21(20)26(28-19)30-15-13-29(14-16-30)12-6-11-27-23-18-25(31)32-24-10-5-4-9-22(23)24/h2-5,7-10,17-18,27H,6,11-16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518942 (CHEMBL4515683) Show SMILES O=c1cc(OCCCN2CCN(CC2)c2nccc3ccccc23)c2ccccc2o1 Show InChI InChI=1S/C25H25N3O3/c29-24-18-23(21-8-3-4-9-22(21)31-24)30-17-5-12-27-13-15-28(16-14-27)25-20-7-2-1-6-19(20)10-11-26-25/h1-4,6-11,18H,5,12-17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518929 (CHEMBL4585210) Show SMILES CN(CCCN1CCN(CC1)c1nccc2ccccc12)c1cc(=O)oc2ccccc12 Show InChI InChI=1S/C26H28N4O2/c1-28(23-19-25(31)32-24-10-5-4-9-22(23)24)13-6-14-29-15-17-30(18-16-29)26-21-8-3-2-7-20(21)11-12-27-26/h2-5,7-12,19H,6,13-18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518916 (CHEMBL4559061) Show SMILES O=C1CN(CCN1CCCNc1cc(=O)oc2ccccc12)c1nccc2ccccc12 Show InChI InChI=1S/C25H24N4O3/c30-23-17-29(25-19-7-2-1-6-18(19)10-12-27-25)15-14-28(23)13-5-11-26-21-16-24(31)32-22-9-4-3-8-20(21)22/h1-4,6-10,12,16,26H,5,11,13-15,17H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518914 (CHEMBL4451890) Show SMILES O=c1cc(NCCCN2CCN(CC2)c2nccc3ncccc23)c2ccccc2o1 Show InChI InChI=1S/C24H25N5O2/c30-23-17-21(18-5-1-2-7-22(18)31-23)26-10-4-12-28-13-15-29(16-14-28)24-19-6-3-9-25-20(19)8-11-27-24/h1-3,5-9,11,17,26H,4,10,12-16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50223597 (CHEMBL95777) Show SMILES Clc1cccc(c1)-n1nc(cc1\C=C\c1c[nH]c2ccc(Cl)cc12)C1CCNCC1 Show InChI InChI=1S/C24H22Cl2N4/c25-18-2-1-3-20(12-18)30-21(14-24(29-30)16-8-10-27-11-9-16)6-4-17-15-28-23-7-5-19(26)13-22(17)23/h1-7,12-16,27-28H,8-11H2/b6-4+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibitory activity against decatenation of DNA topoisomerase IV isolated from Escherichia coli				Bioorg Med Chem Lett 15: 4299-303 (2005) Article DOI: 10.1016/j.bmcl.2005.06.103 BindingDB Entry DOI: 10.7270/Q2RJ4N7G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50223617 (CHEMBL95778) Show SMILES Cn1cc(\C=C\c2cc(nn2-c2cccc(Cl)c2)C2CCNCC2)c2cc(Cl)ccc12 Show InChI InChI=1S/C25H24Cl2N4/c1-30-16-18(23-14-20(27)6-8-25(23)30)5-7-22-15-24(17-9-11-28-12-10-17)29-31(22)21-4-2-3-19(26)13-21/h2-8,13-17,28H,9-12H2,1H3/b7-5+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibitory activity against decatenation of DNA topoisomerase IV isolated from Escherichia coli				Bioorg Med Chem Lett 15: 4299-303 (2005) Article DOI: 10.1016/j.bmcl.2005.06.103 BindingDB Entry DOI: 10.7270/Q2RJ4N7G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) Show SMILES OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518952 (CHEMBL4476525) Show SMILES Fc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5CCS(=O)(=O)Cc45)CC3)c2c1 Show InChI InChI=1S/C24H27FN4O4S/c25-18-3-2-17-4-7-27-24(19(17)14-18)29-11-9-28(10-12-29)8-1-6-26-21-15-23(30)33-22-5-13-34(31,32)16-20(21)22/h2-4,7,14-15,26H,1,5-6,8-13,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518930 (CHEMBL4453061) Show SMILES Fc1ccc2ccnc(N3CCN(CCCNc4cc(=O)oc5CCOCc45)CC3)c2c1 Show InChI InChI=1S/C24H27FN4O3/c25-18-3-2-17-4-7-27-24(19(17)14-18)29-11-9-28(10-12-29)8-1-6-26-21-15-23(30)32-22-5-13-31-16-20(21)22/h2-4,7,14-15,26H,1,5-6,8-13,16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50475386 (CHEMBL194702) Show SMILES Clc1ccc(COc2ccc(\C=C\c3cc([nH]n3)C3CCNCC3)cc2)cc1Cl Show InChI InChI=1S/C23H23Cl2N3O/c24-21-8-4-17(13-22(21)25)15-29-20-6-2-16(3-7-20)1-5-19-14-23(28-27-19)18-9-11-26-12-10-18/h1-8,13-14,18,26H,9-12,15H2,(H,27,28)/b5-1+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibitory activity against decatenation of DNA topoisomerase IV isolated from Escherichia coli				Bioorg Med Chem Lett 15: 4299-303 (2005) Article DOI: 10.1016/j.bmcl.2005.06.103 BindingDB Entry DOI: 10.7270/Q2RJ4N7G
					More data for this Ligand-Target Pair
DNA topoisomerase 4 subunit A (Escherichia coli (strain K12))	BDBM50518945 (CHEMBL4544573) Show SMILES O=C(NCCCN1CCN(CC1)c1nccc2ccccc12)c1ccccc1 Show InChI InChI=1S/C23H26N4O/c28-23(20-8-2-1-3-9-20)25-12-6-14-26-15-17-27(18-16-26)22-21-10-5-4-7-19(21)11-13-24-22/h1-5,7-11,13H,6,12,14-18H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Angelini S.p.A. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...				J Med Chem 62: 7445-7472 (2019) Article DOI: 10.1021/acs.jmedchem.9b00394 BindingDB Entry DOI: 10.7270/Q2Z03CKM
					More data for this Ligand-Target Pair