Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribonucleoside-diphosphate reductase large subunit (Homo sapiens (Human)) | BDBM50247408 (CHEMBL4067105) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Competitive inhibition of human RRM1 expressed in Escherichia coli BL21-codon plus(DE3)-RIL using [14C]-ADP as substrate | J Med Chem 61: 666-680 (2018) Article DOI: 10.1021/acs.jmedchem.7b00530 BindingDB Entry DOI: 10.7270/Q2W098CB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribonucleoside-diphosphate reductase large subunit/subunit M2 B (Homo sapiens (Human)) | BDBM50497567 (CHEMBL3337770) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Competitive inhibition of human recombinant ribonucleotide reductase in presence of varying levels of ATP by Dixon plot | Bioorg Med Chem Lett 24: 5304-9 (2014) Article DOI: 10.1016/j.bmcl.2014.09.046 BindingDB Entry DOI: 10.7270/Q22Z18H9 | |||||||||||
More data for this Ligand-Target Pair |