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Compile Data Set for Download or QSAR

Found 76 hits of ec50 for UniProtKB: P47869   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50001728
PNG
(8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,...)
Show SMILES Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:6|
Show InChI InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
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n/an/an/an/a 12n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120783
PNG
(8-Benzyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-18-9-5-4-8-16(18)20-14-27-21(24-20)17-13-26(11-10-19(17)25-22(27)28)12-15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,25,28)
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n/an/an/an/a 20n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120779
PNG
(8-(4-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-14-7-5-13(6-8-14)21(29)27-10-9-18-16(11-27)20-25-19(12-28(20)22(30)26-18)15-3-1-2-4-17(15)24/h1-8,12H,9-11H2,(H,26,30)
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n/an/an/an/a 55n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120794
PNG
(2-(2-Fluoro-phenyl)-8-thiophen-2-ylmethyl-6,7,8,9-...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cccs3)CCc1[nH]c2=O
Show InChI InChI=1S/C20H17FN4OS/c21-16-6-2-1-5-14(16)18-12-25-19(22-18)15-11-24(10-13-4-3-9-27-13)8-7-17(15)23-20(25)26/h1-6,9,12H,7-8,10-11H2,(H,23,26)
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n/an/an/an/a 67n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120777
PNG
(8-(3-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1cccc(c1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-14-5-3-4-13(10-14)21(29)27-9-8-18-16(11-27)20-25-19(12-28(20)22(30)26-18)15-6-1-2-7-17(15)24/h1-7,10,12H,8-9,11H2,(H,26,30)
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n/an/an/an/a 70n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120801
PNG
(2-(2-Fluoro-phenyl)-8-pyrimidin-2-yl-6,7,8,9-tetra...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CCc1[nH]c2=O)c1ncccn1
Show InChI InChI=1S/C19H15FN6O/c20-14-5-2-1-4-12(14)16-11-26-17(23-16)13-10-25(18-21-7-3-8-22-18)9-6-15(13)24-19(26)27/h1-5,7-8,11H,6,9-10H2,(H,24,27)
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n/an/an/an/a 84n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120775
PNG
(2-(2-Fluoro-phenyl)-8-pyridin-4-ylmethyl-6,7,8,9-t...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3ccncc3)CCc1[nH]c2=O
Show InChI InChI=1S/C21H18FN5O/c22-17-4-2-1-3-15(17)19-13-27-20(24-19)16-12-26(10-7-18(16)25-21(27)28)11-14-5-8-23-9-6-14/h1-6,8-9,13H,7,10-12H2,(H,25,28)
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n/an/an/an/a 99n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120782
PNG
(2-(2-Fluoro-phenyl)-8-pyridin-3-ylmethyl-6,7,8,9-t...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cccnc3)CCc1[nH]c2=O
Show InChI InChI=1S/C21H18FN5O/c22-17-6-2-1-5-15(17)19-13-27-20(24-19)16-12-26(9-7-18(16)25-21(27)28)11-14-4-3-8-23-10-14/h1-6,8,10,13H,7,9,11-12H2,(H,25,28)
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n/an/an/an/a 101n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120772
PNG
(2-(2-Fluoro-phenyl)-8-propionyl-6,7,8,9-tetrahydro...)
Show SMILES CCC(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C18H17FN4O2/c1-2-16(24)22-8-7-14-12(9-22)17-20-15(10-23(17)18(25)21-14)11-5-3-4-6-13(11)19/h3-6,10H,2,7-9H2,1H3,(H,21,25)
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n/an/an/an/a 110n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120795
PNG
(2-(2-Fluoro-phenyl)-8-(2-methyl-benzoyl)-6,7,8,9-t...)
Show SMILES Cc1ccccc1C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-2-3-7-15(14)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-8-4-5-9-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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n/an/an/an/a 134n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120812
PNG
(8-Benzyl-2-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Show SMILES COc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O2/c1-29-18-9-7-17(8-10-18)21-15-27-22(24-21)19-14-26(12-11-20(19)25-23(27)28)13-16-5-3-2-4-6-16/h2-10,15H,11-14H2,1H3,(H,25,28)
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n/an/an/an/a 143n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120781
PNG
(8-Benzyl-2-(3-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1cccc(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-17-8-4-7-16(11-17)20-14-27-21(24-20)18-13-26(10-9-19(18)25-22(27)28)12-15-5-2-1-3-6-15/h1-8,11,14H,9-10,12-13H2,(H,25,28)
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n/an/an/an/a 154n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120809
PNG
(8-Benzyl-2-phenyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-t...)
Show SMILES O=c1[nH]c2CCN(Cc3ccccc3)Cc2c2nc(cn12)-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c27-22-24-19-11-12-25(13-16-7-3-1-4-8-16)14-18(19)21-23-20(15-26(21)22)17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,24,27)
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n/an/an/an/a 184n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120790
PNG
(8-Benzyl-2-(2,5-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Show SMILES Fc1ccc(F)c(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H18F2N4O/c23-15-6-7-18(24)16(10-15)20-13-28-21(25-20)17-12-27(9-8-19(17)26-22(28)29)11-14-4-2-1-3-5-14/h1-7,10,13H,8-9,11-12H2,(H,26,29)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164567
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13BrCl2N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 190n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120791
PNG
(8-Cyclohexylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-tet...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC3CCCCC3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H25FN4O/c23-18-9-5-4-8-16(18)20-14-27-21(24-20)17-13-26(11-10-19(17)25-22(27)28)12-15-6-2-1-3-7-15/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,25,28)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120776
PNG
(8-Benzyl-2-(2,4-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Show SMILES Fc1ccc(-c2cn3c(n2)c2CN(Cc4ccccc4)CCc2[nH]c3=O)c(F)c1
Show InChI InChI=1S/C22H18F2N4O/c23-15-6-7-16(18(24)10-15)20-13-28-21(25-20)17-12-27(9-8-19(17)26-22(28)29)11-14-4-2-1-3-5-14/h1-7,10,13H,8-9,11-12H2,(H,26,29)
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n/an/an/an/a 210n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120799
PNG
(8-(3,4-Difluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8...)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H15F3N4O2/c23-15-4-2-1-3-13(15)19-11-29-20(26-19)14-10-28(8-7-18(14)27-22(29)31)21(30)12-5-6-16(24)17(25)9-12/h1-6,9,11H,7-8,10H2,(H,27,31)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120789
PNG
(8-Benzyl-2-(4-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-17-8-6-16(7-9-17)20-14-27-21(24-20)18-13-26(11-10-19(18)25-22(27)28)12-15-4-2-1-3-5-15/h1-9,14H,10-13H2,(H,25,28)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120788
PNG
(8-Butyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H-...)
Show SMILES CCCCN1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C19H21FN4O/c1-2-3-9-23-10-8-16-14(11-23)18-21-17(12-24(18)19(25)22-16)13-6-4-5-7-15(13)20/h4-7,12H,2-3,8-11H2,1H3,(H,22,25)
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n/an/an/an/a 247n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120773
PNG
(8-(2-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1ccccc1C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-16-7-3-1-5-13(16)19-12-28-20(25-19)15-11-27(10-9-18(15)26-22(28)30)21(29)14-6-2-4-8-17(14)24/h1-8,12H,9-11H2,(H,26,30)
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n/an/an/an/a 256n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120786
PNG
(8-Benzyl-2-(3-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Show SMILES COc1cccc(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O2/c1-29-18-9-5-8-17(12-18)21-15-27-22(24-21)19-14-26(11-10-20(19)25-23(27)28)13-16-6-3-2-4-7-16/h2-9,12,15H,10-11,13-14H2,1H3,(H,25,28)
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n/an/an/an/a 268n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120805
PNG
(2-(2-Fluoro-phenyl)-8-propenyl-6,7,8,9-tetrahydro-...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC=C)CCc1[nH]c2=O
Show InChI InChI=1S/C18H17FN4O/c1-2-8-22-9-7-15-13(10-22)17-20-16(11-23(17)18(24)21-15)12-5-3-4-6-14(12)19/h2-6,11H,1,7-10H2,(H,21,24)
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n/an/an/an/a 284n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120808
PNG
(2-(2-Fluoro-phenyl)-8-(4-methyl-benzoyl)-6,7,8,9-t...)
Show SMILES Cc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-8-15(9-7-14)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-4-2-3-5-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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n/an/an/an/a 327n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120774
PNG
(2-(2-Fluoro-phenyl)-8-(4-methoxy-benzoyl)-6,7,8,9-...)
Show SMILES COc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O3/c1-31-15-8-6-14(7-9-15)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-4-2-3-5-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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n/an/an/an/a 383n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50052792
PNG
(CHEBI:7035 | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 407n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50052792
PNG
(CHEBI:7035 | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 410n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164569
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-iodo-phenyl)-1H-imida...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2IN2O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 450n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120798
PNG
(2-(2-Fluoro-phenyl)-8-(3H-imidazol-4-ylmethyl)-6,7...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cnc[nH]3)CCc1[nH]c2=O
Show InChI InChI=1S/C19H17FN6O/c20-15-4-2-1-3-13(15)17-10-26-18(23-17)14-9-25(8-12-7-21-11-22-12)6-5-16(14)24-19(26)27/h1-4,7,10-11H,5-6,8-9H2,(H,21,22)(H,24,27)
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n/an/an/an/a 459n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164557
PNG
(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 600n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 650n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 661n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/an/an/a 737n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O |t:1|
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 820n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O |t:1|
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 832n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay

Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120771
PNG
(8-Benzyl-2-(2-thiophen-2-yl-phenyl)-6,7,8,9-tetrah...)
Show SMILES O=c1[nH]c2CCN(Cc3ccccc3)Cc2c2nc(cn12)-c1ccccc1-c1cccs1
Show InChI InChI=1S/C26H22N4OS/c31-26-28-22-12-13-29(15-18-7-2-1-3-8-18)16-21(22)25-27-23(17-30(25)26)19-9-4-5-10-20(19)24-11-6-14-32-24/h1-11,14,17H,12-13,15-16H2,(H,28,31)
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n/an/an/an/a 879n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164579
PNG
(1-(2,4-Dichloro-phenyl)-2-p-tolyl-1H-imidazole-4-c...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H16Cl2N2O2/c1-3-25-19(24)16-11-23(17-9-8-14(20)10-15(17)21)18(22-16)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50459890
PNG
(Bromophene | CHEBI:70620)
Show SMILES Oc1c(Br)cc(Br)cc1-c1cc(Br)cc(Br)c1O
Show InChI InChI=1S/C12H6Br4O2/c13-5-1-7(11(17)9(15)3-5)8-2-6(14)4-10(16)12(8)18/h1-4,17-18H
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n/an/an/an/a 1.08E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...

Bioorg Med Chem Lett 27: 3207-3218 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.073
BindingDB Entry DOI: 10.7270/Q2MC92NR
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120793
PNG
(8-Cyclopropylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-te...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC3CC3)CCc1[nH]c2=O
Show InChI InChI=1S/C19H19FN4O/c20-15-4-2-1-3-13(15)17-11-24-18(21-17)14-10-23(9-12-5-6-12)8-7-16(14)22-19(24)25/h1-4,11-12H,5-10H2,(H,22,25)
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n/an/an/an/a 1.16E+3n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Homo sapiens (Human))		BDBM50120792
PNG
(8-Benzyl-2-p-tolyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-...)
Show SMILES Cc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O/c1-16-7-9-18(10-8-16)21-15-27-22(24-21)19-14-26(12-11-20(19)25-23(27)28)13-17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3,(H,25,28)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2

J Med Chem 45: 5043-51 (2002)


BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164562
PNG
(CHEMBL192127 | [2-(4-Chloro-phenyl)-1-(2,4-dichlor...)
Show SMILES CN1CCN(CC1)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl3N4O/c1-26-8-10-27(11-9-26)21(29)18-13-28(19-7-6-16(23)12-17(19)24)20(25-18)14-2-4-15(22)5-3-14/h2-7,12-13H,8-11H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164558
PNG
(1,2-Bis-(4-chloro-phenyl)-1H-imidazole-4-carboxyli...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3
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n/an/an/an/a 1.50E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164576
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H15BrCl2N2O2/c1-2-9-26-19(25)16-11-24(17-8-7-14(21)10-15(17)22)18(23-16)12-3-5-13(20)6-4-12/h3-8,10-11H,2,9H2,1H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164566
PNG
(1-(2,4-Dichloro-phenyl)-2-phenyl-1H-imidazole-4-ca...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)15-11-22(16-9-8-13(19)10-14(16)20)17(21-15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/an/an/a 1.80E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164573
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-methoxy-phenyl)-1H-im...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(OC)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H16Cl2N2O3/c1-3-26-19(24)16-11-23(17-9-6-13(20)10-15(17)21)18(22-16)12-4-7-14(25-2)8-5-12/h4-11H,3H2,1-2H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164570
PNG
((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
Show InChI InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164578
PNG
(2-(4-Chloro-phenyl)-1-(3,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)16-10-23(13-7-8-14(20)15(21)9-13)17(22-16)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 2.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164577
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-nitro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(cc1)[N+]([O-])=O)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O4/c1-2-27-18(24)15-10-22(16-8-5-12(19)9-14(16)20)17(21-15)11-3-6-13(7-4-11)23(25)26/h3-10H,2H2,1H3
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n/an/an/an/a 2.40E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164575
PNG
(1-(3-Chloro-phenyl)-2-phenyl-1H-imidazole-4-carbox...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-10-6-9-14(19)11-15)17(20-16)13-7-4-3-5-8-13/h3-12H,2H2,1H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2


(Homo sapiens (Human))		BDBM50164561
PNG
(1,2-Bis-(4-fluoro-phenyl)-1H-imidazole-4-carboxyli...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H14F2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3
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n/an/an/an/a 3.10E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...

J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
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