Compile Data Set for Download or QSAR

Found 5 hits of ec50 for UniProtKB: P48167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine receptor subunit alpha-1/beta (Homo sapiens (Human))	BDBM50229715 (CHEMBL4070615) Show SMILES [H][C@]12CN([C@@H](C)[C@@]1([H])C(=O)N(C)c1ccncc21)S(=O)(=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C19H19N3O5S/c1-11-18-14(13-8-20-6-5-15(13)21(2)19(18)23)9-22(11)28(24,25)12-3-4-16-17(7-12)27-10-26-16/h3-8,11,14,18H,9-10H2,1-2H3/t11-,14+,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...				Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycine receptor subunit alpha-1/beta (Homo sapiens (Human))	BDBM50229711 (CHEMBL4074873) Show SMILES [H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r| Show InChI InChI=1S/C19H17N3O4S/c1-21-17-4-6-20-9-14(17)15-10-22(11-16(15)19(21)23)27(24,25)13-2-3-18-12(8-13)5-7-26-18/h2-9,15-16H,10-11H2,1H3/t15-,16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	171	n/a	n/a	n/a	n/a
Albany College of Pharmacy and Health Sciences Curated by ChEMBL					Assay Description Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...				J Med Chem 61: 2652-2679 (2018) Article DOI: 10.1021/acs.jmedchem.7b00956 BindingDB Entry DOI: 10.7270/Q23B62RZ
					More data for this Ligand-Target Pair
Glycine receptor subunit alpha-1/beta (Homo sapiens (Human))	BDBM50229711 (CHEMBL4074873) Show SMILES [H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r| Show InChI InChI=1S/C19H17N3O4S/c1-21-17-4-6-20-9-14(17)15-10-22(11-16(15)19(21)23)27(24,25)13-2-3-18-12(8-13)5-7-26-18/h2-9,15-16H,10-11H2,1H3/t15-,16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	171	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...				Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR
					More data for this Ligand-Target Pair
Glycine receptor subunit alpha-1/beta (Homo sapiens (Human))	BDBM50464255 (CHEMBL4083687) Show SMILES [H][C@@]12CN(C[C@]1([H])c1ccccc1N(C)C2=O)S(=O)(=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C19H18N2O5S/c1-20-16-5-3-2-4-13(16)14-9-21(10-15(14)19(20)22)27(23,24)12-6-7-17-18(8-12)26-11-25-17/h2-8,14-15H,9-11H2,1H3/t14-,15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay				Eur J Med Chem 137: 63-75 (2017) Article DOI: 10.1016/j.ejmech.2017.05.036 BindingDB Entry DOI: 10.7270/Q2H134PC
					More data for this Ligand-Target Pair
Glycine receptor subunit alpha-1/beta (Homo sapiens (Human))	BDBM50464234 (CHEMBL4284872) Show SMILES COc1ccc(Cl)cc1OC1CN(C1)S(=O)(=O)c1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C17H15ClN2O6S/c1-24-14-5-2-10(18)6-16(14)25-11-8-20(9-11)27(22,23)12-3-4-13-15(7-12)26-17(21)19-13/h2-7,11H,8-9H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay				Eur J Med Chem 137: 63-75 (2017) Article DOI: 10.1016/j.ejmech.2017.05.036 BindingDB Entry DOI: 10.7270/Q2H134PC
					More data for this Ligand-Target Pair