Found 6 hits of ec50 for monomerid = 269901 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269901
((2S,3R)N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)C(C)(C)C)n1-c1c(OC)cccc1OC |r,wD:16.17,18.19,(-8.29,-8.35,;-6.8,-8.75,;-5.71,-7.66,;-6.11,-6.17,;-5.02,-5.09,;-3.54,-5.48,;-3.14,-6.97,;-4.23,-8.06,;-1.65,-7.37,;-1.17,-8.84,;.37,-8.84,;.84,-7.37,;2.18,-6.6,;3.51,-7.37,;2.74,-8.7,;4.28,-8.7,;4.84,-6.6,;4.84,-5.06,;6.18,-7.37,;6.18,-8.91,;7.51,-6.6,;8.84,-7.37,;7.51,-5.06,;8.84,-5.83,;-.4,-6.47,;-.4,-4.93,;-1.74,-4.16,;-3.07,-4.93,;-4.4,-4.16,;-1.74,-2.62,;-.4,-1.85,;.93,-2.62,;.93,-4.16,;2.26,-4.93,;3.6,-4.16,)| Show InChI InChI=1S/C23H31N5O6S/c1-14(20(29)23(2,3)4)35(30,31)27-22-26-25-21(15-10-8-13-18(24-15)34-7)28(22)19-16(32-5)11-9-12-17(19)33-6/h8-14,20,29H,1-7H3,(H,26,27)/t14-,20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this Ligand-Target Pair | |