Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyrotropin-releasing hormone receptor (MOUSE) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
Washington University Curated by ChEMBL | Assay Description Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositol | Bioorg Med Chem Lett 8: 3093-6 (1999) Article DOI: 10.1016/S0960-894X(98)00567-8 BindingDB Entry DOI: 10.7270/Q21R6PP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Mus musculus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay | Eur J Med Chem 111: 72-83 (2016) Article DOI: 10.1016/j.ejmech.2016.01.038 BindingDB Entry DOI: 10.7270/Q28G8NKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Mus musculus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method | Bioorg Med Chem 23: 5641-53 (2015) Article DOI: 10.1016/j.bmc.2015.07.022 BindingDB Entry DOI: 10.7270/Q2JH3NZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (MOUSE) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a |
Washington University Curated by ChEMBL | Assay Description Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cells | J Med Chem 39: 1571-4 (1996) Article DOI: 10.1021/jm960053k BindingDB Entry DOI: 10.7270/Q2H70GGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (MOUSE) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method | Bioorg Med Chem 23: 5641-53 (2015) Article DOI: 10.1016/j.bmc.2015.07.022 BindingDB Entry DOI: 10.7270/Q2JH3NZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (MOUSE) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay | Eur J Med Chem 111: 72-83 (2016) Article DOI: 10.1016/j.ejmech.2016.01.038 BindingDB Entry DOI: 10.7270/Q28G8NKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activity | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.8 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | 7.8 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activity | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Mus musculus) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA | Eur J Med Chem 111: 72-83 (2016) Article DOI: 10.1016/j.ejmech.2016.01.038 BindingDB Entry DOI: 10.7270/Q28G8NKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (MOUSE) | BDBM50072394 (1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA | Eur J Med Chem 111: 72-83 (2016) Article DOI: 10.1016/j.ejmech.2016.01.038 BindingDB Entry DOI: 10.7270/Q28G8NKF | |||||||||||
More data for this Ligand-Target Pair |