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Compile Data Set for Download or QSAR

Found 1 hit of ec50 for monomerid = 50502587   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))		BDBM50502587
PNG
(CHEMBL4463125)
Show SMILES CCc1nc(C)c(o1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)C12CCC(CC(O)=O)(CC1)OC2 |(4.98,-14.22,;6.51,-14.06,;7.13,-12.65,;6.36,-11.32,;7.39,-10.17,;7.06,-8.66,;8.79,-10.79,;8.64,-12.33,;10.13,-10.01,;10.12,-8.47,;11.46,-10.78,;12.79,-10.01,;14.12,-10.78,;15.45,-10.01,;15.45,-8.47,;14.11,-7.7,;12.78,-8.47,;16.78,-7.69,;18.11,-8.46,;19.44,-7.69,;19.44,-6.14,;18.1,-5.38,;16.77,-6.16,;20.77,-5.37,;22.1,-6.14,;23.43,-5.37,;23.43,-3.83,;24.77,-3.06,;26.1,-3.83,;27.43,-3.06,;26.1,-5.37,;22.1,-3.06,;20.76,-3.83,;22.61,-5.12,;21.52,-4.03,)|
Show InChI InChI=1S/C28H30N2O5/c1-3-23-29-18(2)25(35-23)26(33)30-22-10-6-20(7-11-22)19-4-8-21(9-5-19)27-12-14-28(15-13-27,34-17-27)16-24(31)32/h4-11H,3,12-17H2,1-2H3,(H,30,33)(H,31,32)
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PC cid
PC sid
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Article
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n/an/an/an/a 56n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...

ACS Med Chem Lett 10: 1128-1133 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00117
BindingDB Entry DOI: 10.7270/Q28W3HJK
More data for this
Ligand-Target Pair