Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA gyrase subunit A/B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |