Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i... | US Patent US10035794 (2018) BindingDB Entry DOI: 10.7270/Q2RB76M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of wild type APP751 (unknown origin) expressed in CHO cells | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01300 BindingDB Entry DOI: 10.7270/Q27D302Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10035794 (2018) BindingDB Entry DOI: 10.7270/Q2RB76M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US8637508 (2014) BindingDB Entry DOI: 10.7270/Q2JD4VFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequence | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01300 BindingDB Entry DOI: 10.7270/Q27D302Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10035794 (2018) BindingDB Entry DOI: 10.7270/Q2RB76M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US8637508 (2014) BindingDB Entry DOI: 10.7270/Q2JD4VFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequence | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01300 BindingDB Entry DOI: 10.7270/Q27D302Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10035794 (2018) BindingDB Entry DOI: 10.7270/Q2RB76M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10035794 (2018) BindingDB Entry DOI: 10.7270/Q2RB76M3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w... | US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM116247![]() (US10035794, Example 24 | US10683287, Example 35 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human Cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrate | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01300 BindingDB Entry DOI: 10.7270/Q27D302Z | |||||||||||
More data for this Ligand-Target Pair |